Accutane and Zenchent

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using ISOtretinoin and norethindrone is not recommended. ISOtretinoin can cause severe, life-threatening birth defects if the mother takes the medication during pregnancy. Even one dose of ISOtretinoin can cause major birth defects of the baby's ears, eyes, face, skull, heart, and brain. Never use ISOtretinoin if you are pregnant. You must agree in writing to use two specific forms of birth control beginning 30 days before you start taking ISOtretinoin and ending 30 days after you stop taking it. Both a primary and a secondary form of birth control must be used together. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Isotretinoin may decrease the plasma concentrations of contraceptive progestins. The potential mechanism of interaction has not been established. In a study of 26 healthy women receiving isotretinoin 1 mg/kg/day for severe, recalcitrant nodular acne and a contraceptive containing ethinyl estradiol and norethindrone for 2 cycles, the addition of isotretinoin resulted in small and inconsistent, but statistically significant decreases in the plasma concentrations of both contraceptive components. Specifically, mean ethinyl estradiol systemic exposure (AUC) decreased by 9% and norethindrone peak plasma concentration (Cmax) decreased by 11%. These changes were not associated with any statistically significant increases in pharmacodynamic markers of contraceptive effectiveness (concentrations of serum progesterone, luteinizing hormone, and follicle-stimulating hormone), although a majority of the subjects had increases in these measures. Given the substantial intersubject variability observed in both pharmacokinetic and pharmacodynamic measures, an interaction that decreases the effectiveness of contraceptive hormones cannot be ruled out. There have been reports of pregnancy occurring in female patients who have used combined oral contraceptives, as well as transdermal patch/injectable/implantable/vaginal ring hormonal birth control products. These reports were more frequent in female patients who used only a single method of contraception.

MANAGEMENT: The manufacturers caution that microdosed progesterone-only preparations ("minipills") are not an acceptable method of contraception during isotretinoin therapy and should not be used. Combination oral contraceptive pills are considered an acceptable primary form of contraception and may be used (please refer to the product labeling for list of acceptable primary and secondary forms of contraception). Due to the teratogenic risk of isotretinoin, females of reproductive potential must use two methods of effective contraception, at least one of which must be a primary form, for at least 1 month prior to initiation of isotretinoin therapy, during therapy, and for 1 month after discontinuing therapy.

It is not known if hormonal contraceptives differ in their effectiveness when used with Claravis. Therefore, it is critically important for females of reproductive potential to select and commit to use two forms of effective contraception simultaneously, at least one of which must be a primary form

Accutane

Generic Name: isotretinoin

Brand name: Accutane, Amnesteem, Claravis, Sotret, Absorica, Myorisan, Zenatane

Synonyms: n.a.

What is Accutane?

Zenchent

Generic Name: ethinyl estradiol / norethindrone

Brand name: Blisovi 24 Fe, Estrostep Fe, Femcon Fe, Kaitlib FE, Lo Minastrin Fe, Microgestin 24 Fe, Norinyl 1+35, Ortho-Novum 7/7/7, Taytulla, Tri-Norinyl, Zenchent, Blisovi 24 Fe, Blisovi Fe 15/30, Blisovi Fe 1/20, Gildess 24 Fe, Gildess Fe 15/30, Gildess Fe 1/20, Junel Fe 15/30, Junel Fe 1/20, Junel Fe 24, Larin 24 Fe, Larin Fe 15/30, Larin Fe 1/20, Lo Loestrin Fe, Loestrin 24 Fe, Loestrin Fe 15/30, Loestrin Fe 1/20, Lomedia 24 Fe, Microgestin 24 Fe, Microgestin Fe 15/30, Microgestin Fe 1/20, Tarina Fe 1/20, Tilia Fe, Tri-Legest Fe, femhrt 05 mg/25 mcg, Fyavolv, Jevantique Lo, Jinteli, Femcon Fe, Generess FE, Loestrin 1/20, Ovcon 35, Brevicon

Synonyms: Zenchent (birth control)

What is Zenchent?