Acetaminophen and Aspirin (Buffered) and Nitroglycerin Spray
Determining the interaction of Acetaminophen and Aspirin (Buffered) and Nitroglycerin Spray and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Aspirin may enhance the antihypertensive effect of nitroglycerin. The mechanism is unknown but may be mediated though the prostaglandin system. Management consists of monitoring blood pressure during coadministration.
- Weber S, Rey E, Pipeau C, et al "Influence of aspirin on the hemodynamic effects of sublingual nitroglycerin." J Cardiovasc Pharmacol 5 (1983): 874-7
- Rey E, El-Assaf HD, Richard MO, Weber S, Bourdon A, Picard G, Olive G "Pharmacological interaction between nitroglycerin and aspirin after acute and chronic aspirin treatment of healthy subjects." Eur J Clin Pharmacol 25 (1983): 779-82
- Morcillio E, Reid PR, Dubin N, Ghodgaonkar R, Pitt B "Myocardial prostaglandin E release by nitroglycerin and modification by indomethacin." Am J Cardiol 45 (1980): 53-7
- Karlberg KE, Ahlner J, Henriksson P, Torfgard K, Sylven C "Effects of nitroglycerin on platelet aggregation beyond the effects of actylsalicylic acid in healthy subjects." Am J Cardiol 71 (1993): 361-4
Generic Name: acetaminophen / aspirin
Brand name: Excedrin Back & Body
Synonyms: n.a.
Generic Name: nitroglycerin
Brand name: Gonitro, Nitrolingual, NitroMist, Nitrostat, Nitro-Time, Gonitro, Minitran, Nitro TD Patch-A, Nitro-Dur, Nitro-Bid, Nitrol Appli-Kit, Rectiv
Synonyms: Nitroglycerin (oral/sublingual), Nitroglycerin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Acetaminophen and Aspirin (Buffered)-Nitroglycerin Sublingual Powder
- Acetaminophen and Aspirin (Buffered)-Nitroglycerin Sublingual Tablet
- Acetaminophen and Aspirin (Buffered)-Nitroglycerin Sublingual Tablets
- Acetaminophen and Aspirin (Buffered)-Nitroglycerin topical
- Acetaminophen and Aspirin (Buffered)-Nitroglycerin transdermal
- Acetaminophen and Aspirin (Buffered)-Nitroglycerin Transdermal Patch
- Nitroglycerin Spray-Acetaminophen and benzhydrocodone
- Nitroglycerin Spray-Acetaminophen and butalbital
- Nitroglycerin Spray-Acetaminophen and caffeine
- Nitroglycerin Spray-Acetaminophen and chlorpheniramine
- Nitroglycerin Spray-Acetaminophen and codeine
- Nitroglycerin Spray-Acetaminophen and Codeine Oral Solution