Acetaminophen and benzhydrocodone and Zidovudine
Determining the interaction of Acetaminophen and benzhydrocodone and Zidovudine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Case reports have suggested that the concomitant use of zidovudine and acetaminophen may potentiate the risk of bone marrow suppression and hepatotoxicity; however data have been conflicting. The mechanism is unknown. Until more information is available, patients taking both drugs concurrently should be monitored for the development of hepatotoxicity and bone marrow toxicity.
- Gill PS, Rarick M, Brynes RK, et al "Azidothymidine associated with bone marrow failure in the acquired immunodeficiency syndrome (AIDS)." Ann Intern Med 107 (1987): 502-5
- Sattler FR, Ko R, Antoniskis D, et al "Acetaminophen does not impair clearance of zidovudine." Ann Intern Med 114 (1991): 937-40
- Burger DM, Meenhorst PL, Koks CH, Beijnen JH "Drug interactions with zidovudine." AIDS 7 (1993): 445-60
- Goldsmith JC, Irvine W "Reversible agranulocytosis related to azidothymidine therapy." Am J Hematol 30 (1989): 263-4
- Ameer B "Acetaminophen hepatotoxicity augmented by zidovudine." Am J Med 95 (1993): 342
- Shriner K, Goetz MB "Severe hepatoxicity in a patient receiving both acetaminophen and zidovudine." Am J Med 93 (1992): 94-6
Generic Name: acetaminophen / benzhydrocodone
Brand name: Apadaz
Synonyms: Benzhydrocodone and Acetaminophen
Generic Name: zidovudine
Brand name: Retrovir
Synonyms: Zidovudine (oral/injection)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Acetaminophen and benzhydrocodone-Zidovudine Capsules and Tablets
- Acetaminophen and benzhydrocodone-Zidovudine Injection
- Acetaminophen and benzhydrocodone-Zidovudine Intravenous
- Acetaminophen and benzhydrocodone-Zidovudine Oral Solution
- Acetaminophen and benzhydrocodone-Zidovudine oral/injection
- Acetaminophen and benzhydrocodone-Zidovudine Syrup
- Zidovudine-Acetaminophen and butalbital
- Zidovudine-Acetaminophen and caffeine
- Zidovudine-Acetaminophen and chlorpheniramine
- Zidovudine-Acetaminophen and codeine
- Zidovudine-Acetaminophen and Codeine Oral Solution
- Zidovudine-Acetaminophen and Codeine Solution