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Acetaminophen and caffeine and Disulfiram

Determining the interaction of Acetaminophen and caffeine and Disulfiram and the possibility of their joint administration.

Check result:

Acetaminophen and caffeine <> Disulfiram

Relevance: 05.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Disulfiram may increase the cardiovascular and CNS-stimulant effects of caffeine. The mechanism may be related to inhibition of caffeine metabolism in liver microsomes. Patients should be advised to limit their caffeine intake while they are taking disulfiram, particularly if they are experiencing excessive irritability, nervousness or insomnia.

References

Beach CA, Mays DC, Guiler RC, et al "Inhibition of elimination of caffeine by disulfiram in normal subjects and recovering alcoholics." Clin Pharmacol Ther 39 (1986): 265-70

Acetaminophen and caffeine

Generic Name: acetaminophen / caffeine

Brand name: Excedrin Mild Headache, Excedrin Quick Tab Peppermint, Excedrin Quick Tab Spearmint, Excedrin Tension Headache, Excedrin Tension Headache Caplet, Excedrin Tension Headache Express Gels, Excedrin Tension Headache Geltab, Valorin Extra, Excedrin Tension Headache Express

Synonyms: Acetaminophen and Caffeine

What is Acetaminophen and caffeine?

Disulfiram

Generic Name: disulfiram

Brand name: Antabuse

Synonyms: n.a.

What is Disulfiram?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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