Acetaminophen and codeine and Pegvisomant
Determining the interaction of Acetaminophen and codeine and Pegvisomant and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Codeine may reduce the effects of pegvisomant. In clinical trials, patients on narcotic medications often required higher blood levels of pegvisomant to achieve adequate treatment response. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: In clinical trials, patients on opioids often required higher serum pegvisomant concentrations to achieve appropriate IGF-I (insulin-like growth factor-I) suppression compared with patients not receiving opioids. The mechanism of interaction is unknown.
MANAGEMENT: Clinicians should be aware of this potential interaction and adjust the dosage of pegvisomant appropriately in patients treated with opioids.
- "Product Information. Somavert (pegvisomant)." Pharmacia and Upjohn, Kalamazoo, MI.
Generic Name: acetaminophen / codeine
Brand name: Tylenol with Codeine #3, Tylenol with Codeine #4, EZ III, Phenaphen with Codeine, Tylenol with Codeine, Capital and Codeine Suspension, Tylenol with Codeine #2, Vopac, Cocet, Cocet Plus, Capital w/Codeine, Tylenol w/ Codeine
Synonyms: Acetaminophen and Codeine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Acetaminophen and codeine-Pegvisomant Subcutaneous
- Acetaminophen and codeine-Pembrolizumab
- Acetaminophen and codeine-Pembrolizumab Intravenous
- Acetaminophen and codeine-Pemetrexed
- Acetaminophen and codeine-Pemetrexed Disodium
- Acetaminophen and codeine-Pemetrexed Intravenous
- Pegvisomant-Acetaminophen and Codeine Oral Solution
- Pegvisomant-Acetaminophen and Codeine Solution
- Pegvisomant-Acetaminophen and Codeine Suspension
- Pegvisomant-Acetaminophen and Codeine Tablets
- Pegvisomant-Acetaminophen and dextromethorphan
- Pegvisomant-Acetaminophen and Dextromethorphan Liquid