Acetaminophen and dextromethorphan and Sulfinpyrazone
Determining the interaction of Acetaminophen and dextromethorphan and Sulfinpyrazone and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using acetaminophen together with sulfinpyrazone may alter the effects of acetaminophen and cause serious side effects that may affect your liver. Call your doctor immediately if you experience a fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, or yellowing of the skin or the whites of your eyes. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Sulfinpyrazone may increase the potential hepatotoxicity of acetaminophen and decrease its pharmacologic effects. The mechanism may be related to accelerated metabolism of acetaminophen with consequent increased hepatotoxic metabolites. This interaction is of greatest concern in cases of acetaminophen overdose. Data have been limited.
MANAGEMENT: Until more information is available, the use of this combination over a prolonged period of time should probably be avoided. Special dosage adjustments are not needed with normal therapeutic dosages of both agents. Monitoring for clinical and laboratory evidence of hepatotoxicity is recommended.
- Miners JO, Attwood J, Birkett DJ "Determinants of acetaminophen metabolism: effect of inducers and inhibitors of drug metabolism on acetaminophen's metabolic pathways." Clin Pharmacol Ther 35 (1984): 480-6
Generic Name: acetaminophen / dextromethorphan
Brand name: Children's Triacting, Triaminic Cough & Sore Throat, Triaminic Cough & Sore Throat Softchews, Tylenol Childrens Plus Cough & Sore Throat, Tylenol Cough, Drixoral Cough/Sore Throat, Tylenol Cough and Sore Throat Daytime, Children's Tylenol Cold + Cough + Sore Throat, Children's Triaminic Cough and Sore Throat, Childrenâs Tylenol Plus, Triaminic Cough/Sore Throat, Tylenol Cough/Sore Throat
Synonyms: n.a.
Generic Name: sulfinpyrazone
Brand name:
Synonyms: Sulfinpyrazone (Oral)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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