Acetaminophen and oxycodone and DDAVP Rhinal Tube nasal

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

OxyCODONE can sometimes enhance the effects of desmopressin. Although not common, this may increase the risk of developing water retention and a condition known as hyponatremia, which is caused by an abnormal decrease in blood sodium concentration. In serious cases, hyponatremia can lead to seizure, coma, or even death. You should seek immediate medical attention if you experience loss of appetite, nausea, vomiting, drowsiness, fatigue, weakness, headache, confusion, difficulty concentrating, memory impairment, decreased urination, and/or sudden weight gain, as these may be early signs and symptoms of water intoxication and hyponatremia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with opiates may increase the plasma concentrations and pharmacologic effects of oral desmopressin. The risk of water intoxication and/or hyponatremia may be increased. In 18 healthy subjects, loperamide 4 mg given at 24 hours, 12 hours, and 1 hour before a single 400 mcg oral dose of desmopressin increased the peak plasma concentration (Cmax) of desmopressin by 2.3-fold and its systemic exposure (AUC) by 3.1-fold. Pretreatment with loperamide also increased the median time to reach peak desmopressin concentration (Tmax) from 1.3 to 2 hours, but did not affect the terminal elimination half-life. Although not investigated, other opiates may interact similarly with desmopressin by slowing gastrointestinal motility. In addition, some opiate analgesics such as fentanyl, meperidine, morphine, oxycodone, and tramadol have been associated with reports of hyponatremia, sometimes secondary to the syndrome of inappropriate antidiuretic hormone secretion (SIADH). These effects may be additive with those of desmopressin and probably stem from agonist action on morphinic receptors, resulting in increased release of antidiuretic hormone.

MANAGEMENT: Caution is recommended if desmopressin is used in combination with opiates. Serum electrolytes, especially sodium, as well as BUN and creatinine should be monitored regularly. Patients should be advised to seek immediate medical attention if they develop early signs and symptoms of water intoxication or hyponatremia such as anorexia, nausea, vomiting, drowsiness, lethargy, weakness, listlessness, headache, confusion, difficulty concentrating, memory impairment, anuria, and weight gain. Early treatment may help prevent progression to seizure, coma, respiratory arrest, and death.

Acetaminophen and oxycodone

Generic Name:

Brand name: Endocet 10/325, Endocet 25/325, Endocet 5/325, Endocet 75/325, Nalocet, Percocet 10/325, Percocet 25/325, Percocet 5/325, Percocet 75/325, Primalev, Primlev, Roxicet, Xartemis XR, Tylox, Roxilox, Endocet, Percocet 10/650, Percocet 75/500, Perloxx, Magnacet, Narvox, Xolox, Percocet

Synonyms: Oxycodone and Acetaminophen

What is Acetaminophen and oxycodone?

DDAVP Rhinal Tube nasal

Generic Name: desmopressin

Brand name: DDAVP nasal, DDAVP Rhinal Tube, Noctiva, Stimate, DDAVP, Nocdurna

Synonyms: DDAVP Rhinal Tube (nasal), DDAVP Rhinal Tube

What is DDAVP Rhinal Tube nasal?