Acetaminophen and phenyltoloxamine and Ranitidine Hydrochloride
Determining the interaction of Acetaminophen and phenyltoloxamine and Ranitidine Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Animal studies have suggested that ranitidine may potentiate the hepatotoxicity of acetaminophen, however, a double-blind placebo-controlled crossover study has failed to confirm this finding in humans. Acetaminophen dosage adjustments are not indicated.
- Rogers SA, Gale KC, Newton JF, et al "Inhibition by ranitidine of acetaminophen conjugation and its possible role in ranitidine potentiation of acetaminophen-induced hepatotoxicity." J Pharmacol Exp Ther 245 (1988): 887-94
- Jack D, Thomas M, Skidmore IF "Ranitidine and paracetamol metabolism." Lancet 2 (1985): 1067
Generic Name: acetaminophen / phenyltoloxamine
Brand name: Dologesic, Dologesic DF, Aceta-Gesic, Percogesic, Major-gesic, Phenylgesic, Apagesic, Duogesic, Phenagesic, Genasec, Q-Gesic, Uni-Perr, Vitoxapap, Flextra-DS, Dolorex, RhinoFlex, Relagesic, Staflex, Alpain, Flextra-650, Acuflex, Hyflex-650, Hyflex-DS, Lagesic, RhinoFlex 650, Q Flex, Vistra, BeFlex, BP Poly-650, Zgesic, Ali-Flex, Dologen, Flextra DS
Synonyms: n.a.
Generic Name: ranitidine
Brand name: Zantac
Synonyms: Ranitidine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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