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Acetaminophen and pyrilamine and Eluxadoline

Determining the interaction of Acetaminophen and pyrilamine and Eluxadoline and the possibility of their joint administration.

Check result:

Acetaminophen and pyrilamine <> Eluxadoline

Relevance: 17.08.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using eluxadoline together with pyrilamine may increase the risk and/or severity of constipation and other gastrointestinal complications. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should stop taking eluxadoline and contact your doctor if you develop constipation that lasts more than 4 days. Always seek advice from a health care professional before taking any over-the-counter medications for diarrhea. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: The risk of constipation and serious constipation-related adverse reactions may be increased when eluxadoline is used with other drugs that are also associated with this adverse effect. In placebo-controlled studies, constipation occurred in 7% and 8% of patients receiving eluxadoline 75 mg twice daily and 100 mg twice daily, respectively. Approximately 50% of constipation events occurred within the first 2 weeks of treatment, while the majority occurred within the first 3 months. The rates of constipation were similar between eluxadoline and placebo beyond the first 3 months of therapy.

MANAGEMENT: Concomitant use of eluxadoline with other drugs that can cause constipation such as alosetron, anticholinergics, and opioids should generally be avoided. Loperamide may be used occasionally for acute management of severe diarrhea, but chronic use is not recommended, and it should be discontinued immediately if constipation occurs. Eluxadoline should also be discontinued if constipation occurs for more than 4 days.

References

"Product Information. Viberzi (eluxadoline)." Actavis Pharma, Inc., Parsippany, NJ.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Acetaminophen and pyrilamine

Generic Name: acetaminophen / pyrilamine

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Synonyms: n.a.

What is Acetaminophen and pyrilamine?

Eluxadoline

Generic Name: eluxadoline

Brand name: Viberzi

Synonyms: n.a.

What is Eluxadoline?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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