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Acetaminophen and tramadol and Ranitidine

Determining the interaction of Acetaminophen and tramadol and Ranitidine and the possibility of their joint administration.

Check result:

Acetaminophen and tramadol <> Ranitidine

Relevance: 01.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Animal studies have suggested that ranitidine may potentiate the hepatotoxicity of acetaminophen, however, a double-blind placebo-controlled crossover study has failed to confirm this finding in humans. Acetaminophen dosage adjustments are not indicated.

References

Rogers SA, Gale KC, Newton JF, et al "Inhibition by ranitidine of acetaminophen conjugation and its possible role in ranitidine potentiation of acetaminophen-induced hepatotoxicity." J Pharmacol Exp Ther 245 (1988): 887-94
Jack D, Thomas M, Skidmore IF "Ranitidine and paracetamol metabolism." Lancet 2 (1985): 1067

Acetaminophen and tramadol

Generic Name: acetaminophen / tramadol

Brand name: Ultracet

Synonyms: Acetaminophen and Tramadol

What is Acetaminophen and tramadol?

Ranitidine

Generic Name: ranitidine

Brand name: Zantac

Synonyms: n.a.

What is Ranitidine?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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