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Acetaminophen, aspirin, and caffeine and Minitran

Determining the interaction of Acetaminophen, aspirin, and caffeine and Minitran and the possibility of their joint administration.

Check result:

Acetaminophen, aspirin, and caffeine <> Minitran

Relevance: 01.04.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Aspirin may enhance the antihypertensive effect of nitroglycerin. The mechanism is unknown but may be mediated though the prostaglandin system. Management consists of monitoring blood pressure during coadministration.

References

Weber S, Rey E, Pipeau C, et al "Influence of aspirin on the hemodynamic effects of sublingual nitroglycerin." J Cardiovasc Pharmacol 5 (1983): 874-7
Rey E, El-Assaf HD, Richard MO, Weber S, Bourdon A, Picard G, Olive G "Pharmacological interaction between nitroglycerin and aspirin after acute and chronic aspirin treatment of healthy subjects." Eur J Clin Pharmacol 25 (1983): 779-82
Morcillio E, Reid PR, Dubin N, Ghodgaonkar R, Pitt B "Myocardial prostaglandin E release by nitroglycerin and modification by indomethacin." Am J Cardiol 45 (1980): 53-7
Karlberg KE, Ahlner J, Henriksson P, Torfgard K, Sylven C "Effects of nitroglycerin on platelet aggregation beyond the effects of actylsalicylic acid in healthy subjects." Am J Cardiol 71 (1993): 361-4

Acetaminophen, aspirin, and caffeine

Generic Name: acetaminophen / aspirin / caffeine

Brand name: Anacin Advanced Headache Formula, Arthriten, Backaid IPF, Excedrin, Goodys Extra Strength, Goody's Headache Powders, Pain Reliever Plus, Pamprin Max, Uricalm Intensive, Genace, Excedrin Geltab, Supac, Excedrin Migraine, Excedrin Extra Strength, Excedrin Extra Strength Geltab, Excedrin Migraine Geltab, Excedrin Express, Excedrin Menstrual Express, Bayer Migraine Formula, Goodys Headache Powders, Vanquish

Synonyms: n.a.

What is Acetaminophen, aspirin, and caffeine?

Minitran

Generic Name: nitroglycerin

Brand name: Minitran, Nitro TD Patch-A, Nitro-Dur, Gonitro, Nitrolingual, NitroMist, Nitrostat, Nitro-Time, Gonitro, Nitro-Bid, Nitrol Appli-Kit, Rectiv

Synonyms: Minitran (transdermal)

What is Minitran?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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