Acetaminophen, Aspirin, and Caffeine Powder Packet and Diltiazem 12-Hour Sustained-Release Capsules
Determining the interaction of Acetaminophen, Aspirin, and Caffeine Powder Packet and Diltiazem 12-Hour Sustained-Release Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before using dilTIAZem, tell your doctor if you also use aspirin. This combination may cause unusual bleeding or bruising, headache, dizziness, or weakness. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or need your blood pressure checked more often. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Several case reports have suggested that verapamil and aspirin may have synergistic antiplatelet effects. The mechanism of this interaction has not been fully elucidated. Also, one study of five patients has suggested that aspirin may reverse the antihypertensive effect of verapamil. The mechanism may be related to antagonism of the effect of verapamil on prostacyclin. Diltiazem has been shown to interact with aspirin in a similar manner.
MANAGEMENT: Close observation for prolonged bleeding time and reduced antihypertensive effect is recommended if these drugs must be used together. Patients should be advised to notify their physician if they experience unusual bleeding, bruising, or petechiae. Aspirin should be discontinued if an interaction is suspected.
- "Product Information. Covera-HS (verapamil)." Searle, Skokie, IL.
- Das UN "Modification of anti-hypertensive action of verapamil by inhibition of endogenous prostaglandin synthesis." Prostaglandins Leukot Med 9 (1982): 167-9
- Altman R, Scazziota A, Dujovne C "Diltiazem potentiates the inhibitory effect of aspirin on platelet aggregation." Clin Pharmacol Ther 44 (1988): 320-5
- Ring ME, Corrigan JJ, Fenster PE "Effects of oral diltiazem on platelet function: alone and in combination with "low dose" aspirin." Thromb Res 44 (1986): 391-400
- Verzino E, Kaplan B, Ashley JV, Burdette M "Verapamil-aspirin interaction." Ann Pharmacother 28 (1994): 536-7
Generic Name: acetaminophen / aspirin / caffeine
Brand name: Anacin Advanced Headache Formula, Arthriten, Backaid IPF, Excedrin, Goodys Extra Strength, Goody's Headache Powders, Pain Reliever Plus, Pamprin Max, Uricalm Intensive, Genace, Excedrin Geltab, Supac, Excedrin Migraine, Excedrin Extra Strength, Excedrin Extra Strength Geltab, Excedrin Migraine Geltab, Excedrin Express, Excedrin Menstrual Express, Bayer Migraine Formula, Goodys Headache Powders, Vanquish
Synonyms: Acetaminophen, aspirin, and caffeine
Generic Name: diltiazem
Brand name: Cardizem, Cartia XT, Dilacor XR, Dilt-CD, Diltia XT, Dilt-XR, Diltzac, Matzim LA, Taztia XT, Tiazac, Cardizem CD, Tiazac, Cardizem LA, Tiazac Extended Release Capsules
Synonyms: Diltiazem
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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