Acetaminophen, Aspirin, and Caffeine Powder Packet and Metoprolol Tablets
Determining the interaction of Acetaminophen, Aspirin, and Caffeine Powder Packet and Metoprolol Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:High doses of salicylates may blunt the antihypertensive effects of beta-blockers. The proposed mechanism is inhibition of prostaglandin synthesis. Low-dose aspirin does not appear to affect blood pressure. In addition, beta-blockers may exert an antiplatelet effect, which may be additive with the effects of some salicylates. Metoprolol may also increase aspirin absorption and/or plasma concentrations of salicylates; however, the clinical significance of this effect is unknown. Data have been conflicting. Until more information is available, patients who require concomitant therapy should be monitored for altered antihypertensive response whenever a salicylate is introduced or discontinued, or when its dosage is modified.
- Keber I, Jerse M, Keber D, Stegnar M "The influence of combined treatment with propranolol and acetylsalicylic acid on platelet aggregation in coronary heart disease." Br J Clin Pharmacol 7 (1979): 287-91
- Spahn H, Langguth P, Kirch W, et al "Pharmacokinetics of salicylates administered with metoprolol." Arzneimittelforschung 36 (1986): 1697-9
- Sziegoleit W, Rausch J, Polak G, et al "Influence of acetylsalicylic acid on acute circulatory effects of the beta-blocking agents pindolol and propranolol in humans." Int J Clin Pharmacol Ther Toxicol 20 (1982): 423-30
- Sziegoleit W, Rausch J , Polak G, Gyorgy M, Dekov E, Bekes M "Influence of acetylsalicylic acid on acute circulatory effects of the beta-blocking agents pindolol and propranolol." Int J Clin Pharmacol Ther Toxicol 20 (1982): 423-30
- Zanchetti A, Hansson L, Leonetti G, et al. "Low-dose aspirin does not interfere with the blood pressure-lowering effects of antihypertensive therapy." J Hypertens 20 (2002): 1015-1022
- Hartmann D, Stief G, Lingenfelder M, Guzelhan C, Horsch AK "Study on the possible interaction between tenoxicam and atenolol in hypertensive patients." Arzneimittelforschung 45-1 (1995): 494-8
Generic Name: acetaminophen / aspirin / caffeine
Brand name: Anacin Advanced Headache Formula, Arthriten, Backaid IPF, Excedrin, Goodys Extra Strength, Goody's Headache Powders, Pain Reliever Plus, Pamprin Max, Uricalm Intensive, Genace, Excedrin Geltab, Supac, Excedrin Migraine, Excedrin Extra Strength, Excedrin Extra Strength Geltab, Excedrin Migraine Geltab, Excedrin Express, Excedrin Menstrual Express, Bayer Migraine Formula, Goodys Headache Powders, Vanquish
Synonyms: Acetaminophen, aspirin, and caffeine
Generic Name: metoprolol
Brand name: Kapspargo Sprinkle, Lopressor, Toprol-XL, Toprol XL
Synonyms: Metoprolol
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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