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Acetaminophen, butalbital, and caffeine and Dilacor XR

Determining the interaction of Acetaminophen, butalbital, and caffeine and Dilacor XR and the possibility of their joint administration.

Check result:

Acetaminophen, butalbital, and caffeine <> Dilacor XR

Relevance: 25.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Butalbital may reduce the blood levels and effects of dilTIAZem. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration with inducers of CYP450 3A4 may significantly decrease the plasma concentrations of diltiazem, which is primarily metabolized by the isoenzyme. In 13 study subjects, administration of diltiazem (240 mg daily for 21 days) with the CYP450 3A4 inducer efavirenz (600 mg daily for 14 days) decreased diltiazem peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin) by a mean of 60%, 69% and 63%, respectively. Rifampin, a potent CYP450 3A4 inducer, has been reported to lower diltiazem plasma concentrations to undetectable levels.

MANAGEMENT: Use of diltiazem with rifampin or any known CYP450 3A4 inducer should be avoided when possible, and alternative therapy considered. Diltiazem dose adjustment should be guided by clinical response if concomitant use with a CYP450 3A4 inducer is necessary.

References

"Product Information. Sustiva (efavirenz)." DuPont Pharmaceuticals, Wilmington, DE.
Drda KD, Bastian TL, Self TH, et al "Effects of debrisoquine hydroxylation phenotype and enzyme induction with rifampin on diltiazem pharmacokinetics and pharmacodynamics." Pharmacotherapy 11 (1991): 278
Strayhorn VA, Baciewicz AM, Self TH "Update on rifampin drug interactions, III." Arch Intern Med 157 (1997): 2453-8
Borcherding SM, Baciewicz AM, Self TH "Update on rifampin drug interactions." Arch Intern Med 152 (1992): 711-6
"Product Information. Cardizem (diltiazem)." Hoechst Marion-Roussel Inc, Kansas City, MO.

Acetaminophen, butalbital, and caffeine

Generic Name: acetaminophen / butalbital / caffeine

Brand name: Capacet, Esgic, Fioricet, Margesic, Medigesic, Orbivan, Repan, Vanatol LQ, Zebutal, Esgic-Plus, Arcet, Isocet, Pharmagesic, Anoquan, Two-Dyne, Tenake, Anolor 300, Femcet, Geone, Tencet, Triad, Fiorpap, Dolmar, Endolor, Ezol, Ide-cet, G-1, Minotal, Mygracet, Pacaps, Alagesic, Americet, Nonbac, Dolgic LQ, Dolgic Plus, Vanatol S, Alagesic LQ

Synonyms: Butalbital, Acetaminophen, and Caffeine

What is Acetaminophen, butalbital, and caffeine?

Dilacor XR

Generic Name: diltiazem

Brand name: Cardizem, Cartia XT, Dilacor XR, Dilt-CD, Diltia XT, Diltzac, Matzim LA, Taztia XT, Tiazac, Cardizem CD, Dilt-XR, Tiazac, Cardizem LA, Tiazac Extended Release Capsules

Synonyms: Dilacor XR (Oral)

What is Dilacor XR?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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