Acetaminophen, caffeine, and dihydrocodeine and Zidovudine Capsules and Tablets
Determining the interaction of Acetaminophen, caffeine, and dihydrocodeine and Zidovudine Capsules and Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Case reports have suggested that the concomitant use of zidovudine and acetaminophen may potentiate the risk of bone marrow suppression and hepatotoxicity; however data have been conflicting. The mechanism is unknown. Until more information is available, patients taking both drugs concurrently should be monitored for the development of hepatotoxicity and bone marrow toxicity.
- Gill PS, Rarick M, Brynes RK, et al "Azidothymidine associated with bone marrow failure in the acquired immunodeficiency syndrome (AIDS)." Ann Intern Med 107 (1987): 502-5
- Sattler FR, Ko R, Antoniskis D, et al "Acetaminophen does not impair clearance of zidovudine." Ann Intern Med 114 (1991): 937-40
- Burger DM, Meenhorst PL, Koks CH, Beijnen JH "Drug interactions with zidovudine." AIDS 7 (1993): 445-60
- Goldsmith JC, Irvine W "Reversible agranulocytosis related to azidothymidine therapy." Am J Hematol 30 (1989): 263-4
- Ameer B "Acetaminophen hepatotoxicity augmented by zidovudine." Am J Med 95 (1993): 342
- Shriner K, Goetz MB "Severe hepatoxicity in a patient receiving both acetaminophen and zidovudine." Am J Med 93 (1992): 94-6
Generic Name: acetaminophen / caffeine / dihydrocodeine
Brand name: Dvorah, Panlor Tablet, Trezix, Panlor DC, Panlor SS, Zerlor
Synonyms: Acetaminophen, Caffeine, and Dihydrocodeine
Generic Name: zidovudine
Brand name: Retrovir
Synonyms: Zidovudine (oral/injection), Zidovudine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Acetaminophen, caffeine, and dihydrocodeine-Zidovudine Injection
- Acetaminophen, caffeine, and dihydrocodeine-Zidovudine Intravenous
- Acetaminophen, caffeine, and dihydrocodeine-Zidovudine Oral Solution
- Acetaminophen, caffeine, and dihydrocodeine-Zidovudine oral/injection
- Acetaminophen, caffeine, and dihydrocodeine-Zidovudine Syrup
- Acetaminophen, caffeine, and dihydrocodeine-Zidovudine Tablets
- Zidovudine Capsules and Tablets-Acetaminophen, Caffeine, and Isometheptene Mucate
- Zidovudine Capsules and Tablets-Acetaminophen, caffeine, and magnesium salicylate
- Zidovudine Capsules and Tablets-Acetaminophen, Caffeine, and Pyrilamine
- Zidovudine Capsules and Tablets-Acetaminophen, chlorpheniramine, and dextromethorphan
- Zidovudine Capsules and Tablets-Acetaminophen, Chlorpheniramine, and Dextromethorphan Liquid and Syrup
- Zidovudine Capsules and Tablets-Acetaminophen, Chlorpheniramine, and Dextromethorphan Suspension