Acetaminophen, Caffeine, and Isometheptene Mucate and Dihydroergotamine Nasal Spray

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using dihydroergotamine together with isometheptene mucate is generally not recommended. Dihydroergotamine may cause significant increases in blood pressure by constricting the blood vessels, and the risk for complications may be increased when used with other drugs that also have this effect such as decongestants, stimulants, and certain medications for headache, glaucoma, or eye redness relief. Combining these medications may also reduce blood flow to vital organs and increase the risk of rare but serious side effects such as heart attack, stroke, intestinal problems, and gangrene (death of tissues, usually in the arm or leg, that may require surgical amputation). Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should seek immediate medical attention if you experience severe abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, severe or throbbing headache, irregular heartbeat, shortness of breath, blurred vision, confusion, and/or slurred speech during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Additive or synergistic increases in blood pressure and/or ischemic response may occur when ergot alkaloids are combined with peripheral or central vasoconstrictors. Ergot alkaloids produce arterial vasoconstriction by stimulating alpha-adrenergic and serotonin receptors and inhibiting endothelial-derived relaxation factor release. There have been isolated case reports of gangrene in patients treated with intravenous ergonovine followed shortly by dopamine or norepinephrine.

MANAGEMENT: Concomitant use of dihydroergotamine with other vasoconstrictive agents is considered contraindicated by the manufacturer. Patients treated with dihydroergotamine should be advised to seek immediate medical attention if they experience potential symptoms of ischemia such as coldness, pallor, cyanosis, numbness, tingling, or pain in the extremities; muscle weakness; severe or worsening headache; visual disturbances; severe abdominal pain; chest pain; and shortness of breath.

Acetaminophen, Caffeine, and Isometheptene Mucate

Generic Name: acetaminophen / caffeine / isometheptene mucate

Brand name: Prodrin, MigraTen

Synonyms: n.a.

What is Acetaminophen, Caffeine, and Isometheptene Mucate?

Dihydroergotamine Nasal Spray

Generic Name: dihydroergotamine

Brand name: DHE. 45, Migranal

Synonyms: Dihydroergotamine (injection), Dihydroergotamine

What is Dihydroergotamine Nasal Spray?