Acetaminophen, caffeine, and magnesium salicylate and Alti-Valproic

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Before taking magnesium salicylate, tell your doctor if you also use valproic acid. You may need dose adjustments or special tests in order to safely take both medications together. Small single doses of magnesium salicylate are unlikely to cause significant effects. However, if you take magnesium salicylate over a prolonged period of time you may need your valproic acid levels checked. You should notify your doctor if you have symptoms of fever, weakness, drowsiness, nausea, vomiting, or stomach pain. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

MONITOR: Salicylates, particularly aspirin, may displace valproate from protein binding sites and inhibit its clearance. Four-fold increases in the free fraction of valproate have been reported in children. Increased therapeutic and toxic effects may be expected to occur. This interaction is more likely with large or prolonged doses of salicylates.

MANAGEMENT: Small single doses of salicylates are unlikely to cause significant effects. However, patients who take large doses of salicylates or over a prolonged period of time should be closely monitored for clinical and laboratory evidence of valproate toxicity and hepatotoxicity. Free fraction of valproate may be particularly helpful in detecting this interaction. Patients should be advised to notify their physician if they experience possible symptoms of toxicity (e.g., malaise, weakness, lethargy, drowsiness, nausea, vomiting, or abdominal pain).

Acetaminophen, caffeine, and magnesium salicylate

Generic Name: acetaminophen / caffeine / magnesium salicylate

Brand name: KneeRelief

Synonyms: n.a.

What is Acetaminophen, caffeine, and magnesium salicylate?

Alti-Valproic

Generic Name: valproic acid

Brand name: Depakene, Depacon, Stavzor, Valproate Sodium

Synonyms: Valproic acid, Valproic Acid and Derivatives

What is Alti-Valproic?