Acetaminophen, Caffeine, and Pyrilamine and Hycamtin Capsules
Determining the interaction of Acetaminophen, Caffeine, and Pyrilamine and Hycamtin Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:The cytotoxic and cytostatic activity of topotecan may be diminished in the presence of caffeine. The mechanism is probably formation of complexes between caffeine and topotecan which result in reducing the effective concentration of the free form of topotecan. The clinical implications of this interaction are unknown.
- Traganos F, Kapuscinski J, Gong J, Ardelt B, Darzynkiewicz RJ, Darzynkiewicz Z "Caffeine prevents apoptosis and cell cycle effects induced by camptothecin or topotecan in HL-60 cells." Cancer Res 53 (1993): 4613-8
Generic Name: acetaminophen / caffeine / pyrilamine
Brand name: GoodSense Menstrual Relief, Midol Complete
Synonyms: n.a.
Generic Name: topotecan
Brand name: Hycamtin
Synonyms: Topotecan (oral/injection), Topotecan
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Acetaminophen, Caffeine, and Pyrilamine-Hycamtin Intravenous
- Acetaminophen, Caffeine, and Pyrilamine-Hycamtin oral/injection
- Acetaminophen, Caffeine, and Pyrilamine-Hycet
- Acetaminophen, Caffeine, and Pyrilamine-Hycodan
- Acetaminophen, Caffeine, and Pyrilamine-Hycodan Oral
- Acetaminophen, Caffeine, and Pyrilamine-Hycodan Oral Solution
- Hycamtin Capsules-Acetaminophen, chlorpheniramine, and dextromethorphan
- Hycamtin Capsules-Acetaminophen, Chlorpheniramine, and Dextromethorphan Liquid and Syrup
- Hycamtin Capsules-Acetaminophen, Chlorpheniramine, and Dextromethorphan Suspension
- Hycamtin Capsules-Acetaminophen, chlorpheniramine, and phenylephrine
- Hycamtin Capsules-Acetaminophen, Chlorpheniramine, and Phenylephrine Effervescent Tablets
- Hycamtin Capsules-Acetaminophen, Chlorpheniramine, and Phenylephrine Tablets