Acetaminophen, dextromethorphan, and doxylamine and Regimex

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using benzphetamine together with dextromethorphan can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucinations, seizures, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Severe cases may result in coma and even death. The syndrome is most likely to occur when these medications are abused or taken at higher dosages or more frequently than recommended. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration of amphetamines and amphetamine-like drugs with certain opioids or the synthetic opioid derivative, dextromethorphan, may increase the risk of serotonin syndrome. Dextromethorphan and some opioids, particularly those in the phenylpiperidine class, are weak serotonin reuptake inhibitors whose effects may be potentiated by amphetamines. However, clinical data are limited. Case reports of serotonin syndrome involving these agents have primarily been associated with concomitant use of highly serotonergic substances such as selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, monoamine oxidase inhibitors, and other antidepressants. Rarely, except in the case of abuse or overdose, has serotonin syndrome been associated with the use of amphetamines, opioids, or dextromethorphan alone or with each other. In the case of amphetamines, serotonin syndrome has most frequently been reported with the use of MDMA, or ecstasy, an amphetamine derivative with enhanced serotonergic activity over classical amphetamines, which tend to be more dopaminergic. Serotonin syndrome is a rare but serious and potentially fatal condition thought to result from hyperstimulation of 5-HT1A and 2A receptors in the brainstem and peripheral nervous system. Symptoms may include mental status changes such as irritability, altered consciousness, confusion, hallucination, and coma; autonomic dysfunction such as tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, and mydriasis; neuromuscular abnormalities such as hyperreflexia, myoclonus, tremor, rigidity, and ataxia; and gastrointestinal symptoms such as abdominal cramping, nausea, vomiting, and diarrhea.

MANAGEMENT: Caution is recommended when amphetamines and amphetamine-like drugs are used with dextromethorphan or opioids with serotonergic effects such as fentanyl, meperidine, methadone, propoxyphene, and tramadol. Patients should be monitored for symptoms of the serotonin syndrome during treatment. Particular caution is advised when increasing the dosages of these agents. If serotonin syndrome develops or is suspected during the course of therapy, all serotonergic agents should be discontinued immediately and supportive care rendered as necessary. Moderately ill patients may also benefit from the administration of a serotonin antagonist (e.g., cyproheptadine, chlorpromazine). Severe cases should be managed under consultation with a toxicologist and may require sedation, neuromuscular paralysis, intubation, and mechanical ventilation in addition to the other measures.

Acetaminophen, dextromethorphan, and doxylamine

Generic Name: acetaminophen / dextromethorphan / doxylamine

Brand name: All-Nite, Contac Cold+Flu Cooling Night, Coricidin HBP Nighttime Multi-Symptom Cold, Night Time Cold/Flu, Nyquil Cold & Flu, Robitussin Peak Cold Nighttime Cold + Flu, Tylenol Cold & Cough Nighttime Cool Burst, Tylenol Warming Cough & Sore Throat Nightime, Tylenol Cough & Sore Throat Nightime, Tylenol Cough & Sore Throat Night Time, NyQuil Cold/Flu Relief Cherry, NyQuil Cold/Flu Relief, Nite Time Cold & Flu, Cough & Sore Throat Nighttime, Delsym Cough-Cold Nighttime, Sunmark Nite Time Cold and Flu, Delsym Nighttime Cough & Cold, Multi-Symptom Nighttime Cold & Flu Relief, Nyquil Cold & Flu Nighttime, NyQuil Nature Fusion Cold & Flu Nighttime, Clear Cough PM Multi-Symptom, Tylenol Cough/Sore Throat

Synonyms: n.a.

What is Acetaminophen, dextromethorphan, and doxylamine?

Regimex

Generic Name: benzphetamine

Brand name: Didrex, Regimex

Synonyms: n.a.

What is Regimex?