Acetaminophen, dextromethorphan, doxylamine, and phenylephrine and Adhansia XR
Determining the interaction of Acetaminophen, dextromethorphan, doxylamine, and phenylephrine and Adhansia XR and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Both phenylephrine and methylphenidate can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Central nervous system (CNS) stimulants, particularly the amphetamines, can potentiate the adrenergic response to vasopressors and other sympathomimetic agents. Additive increases in blood pressure and heart rate may occur due to enhanced peripheral sympathetic activity.
MANAGEMENT: Caution is advised if CNS stimulants are used with vasopressors or other sympathomimetic agents. Pulse and blood pressure should be closely monitored.
- "Product Information. Sanorex (mazindol)" Novartis Pharmaceuticals, East Hanover, NJ.
- "Product Information. Strattera (atomoxetine)." Lilly, Eli and Company, Indianapolis, IN.
- Rosenblatt JE, Lake CR, van Kammen DP, Ziegler MG, Bunney WE Jr "Interactions of amphetamine, pimozide, and lithium on plasma norepineophrine and dopamine-beta-hydroxylase in schizophrenic patients." Psychiatry Res 1 (1979): 45-52
- "Product Information. Tenuate (diethylpropion)" Aventis Pharmaceuticals, Swiftwater, PA.
- "Product Information. Adderall (amphetamine-dextroamphetamine)" Shire Richwood Pharmaceutical Company, Florence, KY.
- "Product Information. Focalin (dexmethylphenidate)." Mikart Inc, Atlanta, GA.
- Cavanaugh JH, Griffith JD, Oates JA "Effect of amphetamine on the pressor response to tyramine: formation of p-hydroxynorephedrine from amphetamine in man." Clin Pharmacol Ther 11 (1970): 656
Generic Name: acetaminophen / dextromethorphan / doxylamine / phenylephrine
Brand name: Alka-Seltzer Plus Night-Time Cold, Delsym Adult Night Time Multi-Symptom, Mucinex Fast-Max Night Time Cold & Flu, NyQuil Severe Cold & Flu, Tylenol Cold Multi-Symptom Nighttime, Tylenol Warming Cold Multi-Symptom Nighttime, Tylenol Cold Plus Flu Plus Cough Night
Synonyms: n.a.
Generic Name: methylphenidate
Brand name: Adhansia XR, Aptensio XR, Concerta, Cotempla XR-ODT, Jornay PM, Metadate ER, Methylin, QuilliChew ER, Quillivant XR, Relexxii, Ritalin, Ritalin LA, Metadate CD, Ritalin SR, Daytrana, Methylin ER
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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