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Acetaminophen, dextromethorphan, guaifenesin, and phenylephrine and Levodopa inhalation

Determining the interaction of Acetaminophen, dextromethorphan, guaifenesin, and phenylephrine and Levodopa inhalation and the possibility of their joint administration.

Check result:

Acetaminophen, dextromethorphan, guaifenesin, and phenylephrine <> Levodopa inhalation

Relevance: 04.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Both levodopa and phenylephrine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration with levodopa may potentiate the cardiovascular effects of sympathomimetic agents (e.g., epinephrine, norepinephrine, isoproterenol, amphetamine). Additive increases in blood pressure and heart rate may occur due to enhanced sympathetic activity. However, data evaluating the interaction are not available.

MANAGEMENT: The use of levodopa with sympathomimetic agents should generally be avoided. If concomitant use is required, close monitoring of the cardiovascular system is recommended and the dose of the sympathomimetic agent may need to be reduced.

References

Cerner Multum, Inc. "Australian Product Information." O 0
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Acetaminophen, dextromethorphan, guaifenesin, and phenylephrine

Generic Name: acetaminophen / dextromethorphan / guaifenesin / phenylephrine

Brand name: DayQuil Severe Cold & Flu, Delsym Cough Plus Cold Day Time, Mucinex Children's Cold, Cough & Sore Throat, Mucinex Fast-Max Severe Cold, Sudafed PE Cold & Cough, Tylenol Cold & Flu Severe, Tylenol Cold Multi-Symptom Severe, Mucinex Sinus-Max, Sudafed PE Cold/Cough, Tylenol Cold Head Congestion, Tylenol Cold Multi Symptom, Tylenol Cold/Flu Severe, Vicks DayQuil Severe Cold/Flu

Synonyms: n.a.

What is Acetaminophen, dextromethorphan, guaifenesin, and phenylephrine?

Levodopa inhalation

Generic Name: levodopa

Brand name: Inbrija, Dopar, Larodopa

Synonyms: Levodopa (Oral Inhalation)

What is Levodopa inhalation?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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