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Acetaminophen, dextromethorphan, guaifenesin, and phenylephrine and Mecamylamine

Determining the interaction of Acetaminophen, dextromethorphan, guaifenesin, and phenylephrine and Mecamylamine and the possibility of their joint administration.

Check result:

Acetaminophen, dextromethorphan, guaifenesin, and phenylephrine <> Mecamylamine

Relevance: 04.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using phenylephrine together with mecamylamine may cause an increase in blood pressure. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or need your blood pressure checked more often to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Limited data suggest that methyldopa and other sympatholytics may increase or prolong the pressor effect of sympathomimetics. Hypertension may result. Data exist for phenylpropanolamine and norepinephrine.

MANAGEMENT: If these drugs must be coadministered, blood pressure should be closely monitored. Discontinuation of the sympathomimetic may be necessary if hypertension develops.

References

McLaren EH "Severe hypertension produced by interaction of phenylpropanolamine with methyldopa and oxprenolol." Br Med J 2 (1976): 283-4
"Product Information. Allegra-D (fexofenadine-pseudoephedrine)." Chattem Consumer Products, Chattanooga, TN.

Acetaminophen, dextromethorphan, guaifenesin, and phenylephrine

Generic Name: acetaminophen / dextromethorphan / guaifenesin / phenylephrine

Brand name: DayQuil Severe Cold & Flu, Delsym Cough Plus Cold Day Time, Mucinex Children's Cold, Cough & Sore Throat, Mucinex Fast-Max Severe Cold, Sudafed PE Cold & Cough, Tylenol Cold & Flu Severe, Tylenol Cold Multi-Symptom Severe, Mucinex Sinus-Max, Sudafed PE Cold/Cough, Tylenol Cold Head Congestion, Tylenol Cold Multi Symptom, Tylenol Cold/Flu Severe, Vicks DayQuil Severe Cold/Flu

Synonyms: n.a.

What is Acetaminophen, dextromethorphan, guaifenesin, and phenylephrine?

Mecamylamine

Generic Name: mecamylamine

Brand name: Inversine, Vecamyl

Synonyms: n.a.

What is Mecamylamine?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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