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Acetaminophen, dextromethorphan, guaifenesin, and phenylephrine and Safinamide

Determining the interaction of Acetaminophen, dextromethorphan, guaifenesin, and phenylephrine and Safinamide and the possibility of their joint administration.

Check result:
Acetaminophen, dextromethorphan, guaifenesin, and phenylephrine <> Safinamide
Relevance: 04.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using safinamide together with dextromethorphan may increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Your doctor may be able to prescribe alternatives that do not interact, or you may need more frequent monitoring to safely use both medications. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: By inhibiting serotonin metabolism, monoamine oxidase inhibitors (MAOIs), including the selective MAO-B inhibitor safinamide, may potentiate the pharmacologic activity of serotonergic agents such as dextromethorphan. The result may be an increased risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 2A receptors. Symptoms of the serotonin syndrome may include mental status changes such as irritability, altered consciousness, confusion, hallucinations, and coma; autonomic dysfunction such as tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, and mydriasis; neuromuscular abnormalities such as hyperreflexia, myoclonus, tremor, rigidity, and ataxia; and gastrointestinal symptoms such as abdominal cramping, nausea, vomiting, and diarrhea.

MANAGEMENT: Coadministration of safinamide with dextromethorphan is considered contraindicated.

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Acetaminophen, dextromethorphan, guaifenesin, and phenylephrine

Generic Name: acetaminophen / dextromethorphan / guaifenesin / phenylephrine

Brand name: DayQuil Severe Cold & Flu, Delsym Cough Plus Cold Day Time, Mucinex Children's Cold, Cough & Sore Throat, Mucinex Fast-Max Severe Cold, Sudafed PE Cold & Cough, Tylenol Cold & Flu Severe, Tylenol Cold Multi-Symptom Severe, Mucinex Sinus-Max, Sudafed PE Cold/Cough, Tylenol Cold Head Congestion, Tylenol Cold Multi Symptom, Tylenol Cold/Flu Severe, Vicks DayQuil Severe Cold/Flu

Synonyms: n.a.

What is Acetaminophen, dextromethorphan, guaifenesin, and phenylephrine?
Safinamide

Generic Name: safinamide

Brand name: Xadago

Synonyms: n.a.

What is Safinamide?
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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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