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Acetaminophen/Dextromethorphan/Guaifenesin/Pseudoephedrine Powder Packs and Uptravi

Determining the interaction of Acetaminophen/Dextromethorphan/Guaifenesin/Pseudoephedrine Powder Packs and Uptravi and the possibility of their joint administration.

Check result:
Acetaminophen/Dextromethorphan/Guaifenesin/Pseudoephedrine Powder Packs <> Uptravi
Relevance: 14.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using pseudoephedrine together with selexipag. Using these medications together can make selexipag less effective. You should be counseled to consult with your doctor before taking over-the-counter decongestants. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Concurrent administration of decongestants or vasoconstrictors may negate the vasodilatory effects of prostacyclin analogs in patients with pulmonary hypertension.

MANAGEMENT: The use of decongestants and vasoconstrictors should probably be avoided in patients with pulmonary hypertension. Patients should be counseled to consult with their physician before taking over-the-counter decongestants such as phenylephrine and pseudoephedrine.

References
  • Hardman JG, Gilman AG, Limbird LE eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 9th ed." New York, NY: McGraw-Hill (1995):
  • "Product Information. Remodulin (treprostinil)." United Therapeutics Corp, Silver Spring, MD.
  • "Product Information. Flolan (epoprostenol)." Glaxo Wellcome, Research Triangle Park, NC.
Acetaminophen/Dextromethorphan/Guaifenesin/Pseudoephedrine Powder Packs

Generic Name: acetaminophen / dextromethorphan / guaifenesin / pseudoephedrine

Brand name: Duraflu, Robitussin Cold Cough and Flu, Theraflu Max-D Severe Cold & Flu, Sudafed Cold and Cough Liquicaps, Theraflu Chest and Cough, Tylenol Cold Severe Congestion Non-Drowsy, Sudafed Sinus and Cold Liquicaps, Phlemgesic, Maxiflu DM, Flutabs, Tylenol Cold Severe Congestion

Synonyms: Acetaminophen, dextromethorphan, guaifenesin, and pseudoephedrine

Uptravi

Generic Name: selexipag

Brand name: Uptravi, Uptravi Titration Pack

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.