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Acetaminophen, Diphenhydramine, and Phenylephrine Tablets and Xyzal (Levocetirizine Oral Solution)

Determining the interaction of Acetaminophen, Diphenhydramine, and Phenylephrine Tablets and Xyzal (Levocetirizine Oral Solution) and the possibility of their joint administration.

Check result:
Acetaminophen, Diphenhydramine, and Phenylephrine Tablets <> Xyzal (Levocetirizine Oral Solution)
Relevance: 28.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using levocetirizine together with diphenhydrAMINE may increase side effects such as dizziness, drowsiness, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid driving, operating machinery, or engaging in potentially hazardous activities requiring mental alertness and motor coordination until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Concurrent use of cetirizine or levocetirizine with alcohol or other agents that exhibit central nervous system (CNS) depressant effects may result in additive impairment of mental alertness and performance. Several studies have shown no effect of racemic cetirizine on cognitive function, motor performance, or sleep latency as indicated by objective measurements. However, there have been reports of somnolence, fatigue, and asthenia in some patients treated with cetirizine or levocetirizine in clinical trials.

MANAGEMENT: Concomitant use of cetirizine or levocetirizine with alcohol or other CNS depressants should generally be avoided if possible. In the event that they are used together, patients should be counseled against driving, operating machinery, or engaging in potentially hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

References
  • "Product Information. Zyrtec (cetirizine)." Pfizer US Pharmaceuticals, New York, NY.
  • "Product Information. Xyzal (levocetirizine)." UCB Pharma Inc, Smyrna, GA.
Acetaminophen, Diphenhydramine, and Phenylephrine Tablets

Generic Name: acetaminophen / diphenhydramine / phenylephrine

Brand name: Benadryl Allergy & Sinus Headache, Delsym Cough Plus Cold Night Time, Mucinex Fast-Max Night Time Cold and Flu, Robitussin Nighttime Multi-Symptom Cold, Sudafed PE Severe Cold, Theraflu Severe Cold & Cough Nighttime, Theraflu Warming Flu & Sore Throat, Theraflu Warming Sinus & Cold, Theraflu Warming Severe Cold Nighttime, Benadryl Allergy & Cold, Sudafed PE Nighttime Cold, Tylenol Allergy Multi-Symptom Nighttime, Theraflu Nighttime Severe Cough & Cold, Children's Delsym Cough Plus Cold Night Time, Children's Mucinex Night Multi-Symp Cold, Children's Dimetapp Multi-Symptom Cold & Flu, Theraflu ExpressMax Nighttime Severe C&C, Theraflu PowerPods Nighttime Severe Cold, Benadryl Allergy/Cold, Tylenol Allergy Multi-Symptom, Theraflu Warming Relief Nighttime Severe Cold

Synonyms: Acetaminophen, diphenhydramine, and phenylephrine

Xyzal (Levocetirizine Oral Solution)

Generic Name: levocetirizine

Brand name: Xyzal, LEVRIX, XYZALL

Synonyms: Xyzal

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.