Acetaminophen, Guaifenesin, and Phenylephrine and Treprostinil Sodium
Determining the interaction of Acetaminophen, Guaifenesin, and Phenylephrine and Treprostinil Sodium and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ask your doctor before using phenylephrine together with treprostinil. Using these medications together can make treprostinil less effective. You should be counseled to consult with your doctor before taking over-the-counter decongestants. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Concurrent administration of decongestants or vasoconstrictors may negate the vasodilatory effects of prostacyclin analogs in patients with pulmonary hypertension.
MANAGEMENT: The use of decongestants and vasoconstrictors should probably be avoided in patients with pulmonary hypertension. Patients should be counseled to consult with their physician before taking over-the-counter decongestants such as phenylephrine and pseudoephedrine.
- Hardman JG, Gilman AG, Limbird LE eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 9th ed." New York, NY: McGraw-Hill (1995):
- "Product Information. Remodulin (treprostinil)." United Therapeutics Corp, Silver Spring, MD.
- "Product Information. Flolan (epoprostenol)." Glaxo Wellcome, Research Triangle Park, NC.
Generic Name: acetaminophen / guaifenesin / phenylephrine
Brand name: Theraflu Warming Relief Cold & Chest Congestion
Synonyms: Acetaminophen, Guaifenesin, and Phenylephrine Liquid
Generic Name: treprostinil
Brand name: Orenitram, Remodulin, Tyvaso, Tyvaso Refill Kit, Tyvaso Starter Kit
Synonyms: Treprostinil
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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