Acetaminophen Suspension and Victoza

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Liraglutide delays gastric emptying, which may impact the absorption of concomitantly administered oral medications. In pharmacokinetic studies, liraglutide did not affect the absorption of several orally administered medications to any clinically significant extent (see below). For each interaction studied, administration of the interacting drug was timed so that its absorption peak would coincide with the peak plasma concentration of liraglutide (8 to 12 hours).

Acetaminophen: Administration of a single 1000 mg dose of acetaminophen eight hours after liraglutide dosing (1.8 mg/day) at steady state did not change acetaminophen systemic exposure (AUC). However, acetaminophen peak plasma concentration (Cmax) was decreased by 31% and median time to maximal concentration (Tmax) was delayed up to 15 minutes.

Atorvastatin: Administration of a single 40 mg dose of atorvastatin five hours after liraglutide dosing (1.8 mg/day) at steady state did not change atorvastatin systemic exposure (AUC). However, atorvastatin peak plasma concentration (Cmax) was decreased by 38% and median time to maximal concentration (Tmax) was delayed from 1 hour to 3 hours.

Digoxin: Administration of a single 1 mg dose of digoxin seven hours after liraglutide dosing (1.8 mg/day) at steady state resulted in a 31% and 16% reduction in digoxin peak plasma concentration (Cmax) and systemic exposure (AUC), respectively, and a delay in digoxin median time to maximal concentration (Tmax) from 1 hour to 1.5 hours.

Griseofulvin: Coadministration of a single 500 mg dose of griseofulvin with liraglutide (1.8 mg/day) at steady state did not change griseofulvin systemic exposure (AUC) or median time to maximal concentration (Tmax). However, griseofulvin peak plasma concentration (Cmax) increased by 37%.

Lisinopril: Administration of a single 20 mg dose of lisinopril five minutes after liraglutide dosing (1.8 mg/day) at steady state resulted in a 27% and 15% reduction in lisinopril peak plasma concentration (Cmax) and systemic exposure (AUC), respectively, and a delay in lisinopril median time to maximal concentration (Tmax) from 6 hours to 8 hours.

Oral Contraceptives: Administration of a single 0.03 mg-0.15 mg dose of ethinyl estradiol-levonorgestrel oral contraceptive under fed conditions seven hours after liraglutide dosing (1.8 mg/day) at steady state resulted in a 12% and 13% reduction in the peak plasma concentration (Cmax) of ethinyl estradiol and levonorgestrel, respectively, and a delay in median time to maximal concentration (Tmax) by 1.5 hours for both. Ethinyl estradiol systemic exposure (AUC) was not changed, while levonorgestrel AUC increased by 18%.

Acetaminophen Suspension

Generic Name: acetaminophen

Brand name: Actamin, Anacin AF, Apra, Bromo Seltzer, Children's Tylenol, Elixsure Fever/Pain, Mapap, Medi-Tabs, Q-Pap, Silapap Childrens, Tactinal, Tempra Quicklets, Tycolene, Tylenol, Vitapap, Acephen, Feverall, Children's Silapap, Febrol Solution, Triaminic Fever Reducer, Genapap, Tylenol Junior, Children's Tylenol Meltaways, Junior Tylenol Meltaways, Mapap Infants, Tylenol Infants, Ofirmev, Tylenol 8 Hour, Tylenol Arthritis Pain, Tylophen

Synonyms: Acetaminophen

What is Acetaminophen Suspension?

Victoza

Generic Name: liraglutide

Brand name: Saxenda, Victoza

Synonyms: n.a.

What is Victoza?