Acetazolamide and Maprotiline Hydrochloride

• Generic Name: acetazolamide
• Dosage Forms: n.a.
• Other Brand Names: Diamox, Diamox Sequels

Acetazolamide reduces the activity of a protein in your body called carbonic anhydrase. Blocking this protein can help reduce the build-up of certain fluids in the body.

Acetazolamide is used in people with certain types of glaucoma to reduce the amount of fluid in the eye, which decreases pressure inside the eye.

Acetazolamide is also used as a diuretic ("water pill") in people with congestive heart failure, to reduce the build-up of fluid in the body. This build-up is called edema.

Acetazolamide is also used to treat certain types of seizures, and to treat or prevent altitude sickness.

Acetazolamide may also be used for purposes not listed in this medication guide.

• Generic Name: maprotiline
• Dosage Forms: n.a.
• Other Brand Names: Ludiomil

Management of depressive disorders, including dysthymic disorder (depressive neurosis) and major depressive disorder.

Management of anxiety associated with depression.

Bipolar Disorder

Has been used for the management of acute depressive episodes in bipolar disorder.

However, the American Psychiatric Association (APA) currently does not recommend antidepressant monotherapy for the management of acute depressive episodes in patients with bipolar disorder to avoid precipitation of hypomania or manic episodes. When antidepressants are used in combination with first-line therapies (e.g., lithium, lamotrigine) in patients with bipolar disorder, antidepressants other than TCAs (e.g., bupropion, SSRIs, venlafaxine) generally are preferred.