Acetazolamide Injection Solution and Alprazolam Orally Disintegrating Tablets
Determining the interaction of Acetazolamide Injection Solution and Alprazolam Orally Disintegrating Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:If you are using acetaZOLAMIDE for the prevention of altitude sickness, you should talk to your doctor before using ALPRAZolam. Combining these medications may reduce the effectiveness of acetaZOLAMIDE for this purpose. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Benzodiazepines may counteract the beneficial effects of acetazolamide in preventing altitude sickness by inhibiting respiratory responses to hypoxia. The medical team that accompanied the China-Japan-Nepal Friendship Expedition to Mount Everest in 1988 reports severe hypoventilation in some climbers when acetazolamide and triazolam were given together. One affected climber could be ordered to breath regularly, but repeatedly 'forgot' to continue breathing. This syndrome has been referred to as 'Ondine's curse'.
MANAGEMENT: Caution is recommended if a CAI and a benzodiazepine must be used together. Until more information is available, it may be prudent to avoid the concurrent use of triazolam and acetazolamide at extreme altitudes.
- Masuyama S, Hirata K, Saito A ""Ondine's curse": side effect of acetazolamide?" Am J Med 86 (1989): 637
Generic Name: acetazolamide
Brand name: Diamox, Diamox Sequels
Synonyms: Acetazolamide, AcetaZOLAMIDE
Generic Name: alprazolam
Brand name: Niravam, Xanax, Xanax XR, Alprazolam Intensol
Synonyms: Alprazolam, ALPRAZolam
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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