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Acetazolamide Tablets and Memantine and Donepezil Capsules

Determining the interaction of Acetazolamide Tablets and Memantine and Donepezil Capsules and the possibility of their joint administration.

Check result:
Acetazolamide Tablets <> Memantine and Donepezil Capsules
Relevance: 01.10.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

The concomitant administration of memantine and drugs that alkalinize the urine may decrease the clearance of memantine, resulting in accumulation of memantine and possible increased adverse effects. Memantine clearance decreased by 80% at a urinary pH of 8. The clinical significance is unknown; however, the manufacturer recommends caution.

References
  • "Product Information. Namenda (memantine)." Forest Pharmaceuticals, St. Louis, MO.
Acetazolamide Tablets

Generic Name: acetazolamide

Brand name: Diamox, Diamox Sequels

Synonyms: Acetazolamide, AcetaZOLAMIDE

Memantine and Donepezil Capsules

Generic Name: donepezil / memantine

Brand name: Namzaric, Namzaric Titration Pack

Synonyms: Donepezil and memantine, Memantine and Donepezil

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.