Acetylcholine and Dorzolamide Hydrochloride

• Generic Name: acetylcholine ophthalmic
• Dosage Forms: n.a.
• Other Brand Names: Miochol-E

• It is used during eye surgery.

• Generic Name: dorzolamide ophthalmic
• Dosage Forms: n.a.
• Other Brand Names: Trusopt

Reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.

Fixed-combination preparation containing dorzolamide and timolol (Cosopt) used topically to reduce elevated IOP in patients with open-angle glaucoma or ocular hypertension who have not responded adequately (i.e., failed to achieve target IOP as determined after multiple measurements over time) to a topical β-adrenergic blocking agent. Fixed-combination preparation associated with slightly smaller decrease in IOP than combination therapy with dorzolamide (administered 3 times daily) and timolol (administered twice daily).

A first-line “add-on” agent when more than one drug is needed. Add-on therapy with dorzolamide to existing timolol therapy is as effective and better tolerated than add-on therapy with pilocarpine.

Safety and efficacy not established for the treatment of acute angle-closure glaucoma.

Used prophylactically before neodymium yttrium aluminum garnet (Nd:YAG) laser posterior capsulotomy.

Administration of 1 drop (20 µL) of dorzolamide 2% 1 hour prior to capsulotomy is more effective in preventing postoperative increases in IOP than placebo and as effective as oral acetazolamide 125 mg administered 1 hour prior to the procedure.