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Acid Controller Original Strength and Isentress (Raltegravir Chewable Tablets)

Determining the interaction of Acid Controller Original Strength and Isentress (Raltegravir Chewable Tablets) and the possibility of their joint administration.

Check result:
Acid Controller Original Strength <> Isentress (Raltegravir Chewable Tablets)
Relevance: 27.10.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Since raltegravir solubility is increased at higher pH, coadministration with agents that elevate gastric pH may theoretically increase the plasma concentrations of raltegravir. However, concurrent use of proton pump inhibitors or H2-receptor antagonists in clinical trials did not result in meaningful differences in the safety of raltegravir. Based on these data, no dosage adjustment of raltegravir is necessary when used together with proton pump inhibitors or H2-receptor antagonists.

References
  • "Product Information. Isentress (raltegravir)." Merck & Company Inc, West Point, PA.
Acid Controller Original Strength

Generic Name: famotidine

Brand name: Pepcid, Heartburn Relief, Pepcid AC, Pepcid AC Maximum Strength, Pepcid AC Chewable Tablets, Pepcid Oral Suspension

Synonyms: n.a.

Isentress (Raltegravir Chewable Tablets)

Generic Name: raltegravir

Brand name: Isentress, Isentress HD

Synonyms: Isentress

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.