Acid Controller Original Strength and Lapatinib Ditosylate
Determining the interaction of Acid Controller Original Strength and Lapatinib Ditosylate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using lapatinib together with famotidine. In some patients, famotidine may interfere with the absorption of lapatinib and reduce its effectiveness. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Nonclinical data indicate that the solubility of lapatinib is pH-dependent. Therefore, long-term suppression of gastric acid secretion by H2-receptor antagonists or proton pump inhibitors may reduce lapatinib systemic exposure. In study subjects, coadministration with the proton pump inhibitor esomeprazole (40 mg once daily for 7 days) decreased lapatinib exposure by an average of 27% (range 6% to 49%). This effect decreases with increasing age from approximately 40 to 60 years. The clinical significance is unknown.
MANAGEMENT: Caution may be advisable if lapatinib is used in combination with H2-receptor antagonists or proton pump inhibitors. Patients should be monitored for potentially reduced therapeutic response to lapatinib.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Tykerb (lapatinib)." Novartis Pharmaceuticals, East Hanover, NJ.
Generic Name: famotidine
Brand name: Pepcid, Heartburn Relief, Pepcid AC, Pepcid AC Maximum Strength, Pepcid AC Chewable Tablets, Pepcid Oral Suspension
Synonyms: n.a.
Generic Name: lapatinib
Brand name: Tykerb
Synonyms: Lapatinib
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Acid Controller Original Strength-Lariam
- Acid Controller Original Strength-Larin 1.5/30
- Acid Controller Original Strength-Larin 1/20
- Acid Controller Original Strength-Larin 24 Fe
- Acid Controller Original Strength-Larin Fe 1.5/30
- Acid Controller Original Strength-Larin Fe 1/20
- Lapatinib Ditosylate-Acid Gone
- Lapatinib Ditosylate-Acid Reducer
- Lapatinib Ditosylate-Acid Relief
- Lapatinib Ditosylate-Aciphex
- Lapatinib Ditosylate-Aciphex (Rabeprazole Delayed-Release Tablets)
- Lapatinib Ditosylate-Aciphex (Rabeprazole Sprinkle Capsules)