Aclasta and Etelcalcetide Hydrochloride

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Etelcalcetide can significantly decrease the calcium levels in your blood, and combining it with other medications that also have this effect may increase the risk of hypocalcemia, or low blood calcium. Symptoms of hypocalcemia include numbness or tingling around your mouth, muscle spasms, convulsions, mental changes (irritability, depression, psychosis), increased pressure on the brain, and irregular heartbeat. Let your doctor know if you experience these or other unusual symptoms. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR CLOSELY: Concomitant use of etelcalcetide with other medicines known to lower serum calcium may increase the risk of hypocalcemia. The proposed mechanism is additive reduction in serum calcium levels. Significant decreases in serum calcium may cause paraesthesias, myalgias, muscle spasms, seizures, QT interval prolongation, and ventricular arrhythmia. Etelcalcetide given alone may lead to severe hypocalcemia requiring concomitant treatment with therapies to increase serum calcium levels.

MANAGEMENT: Close monitoring of corrected serum calcium levels is recommended if etelcalcetide is used in combination with other medications known to lower serum calcium, such as denosumab, calcitonin, foscarnet, bisphosphonates, or loop diuretics. It is recommended that the patient's corrected serum calcium level should be measured within one week of initiation or dose adjustment of etelcalcetide and monitored approximately every 4 weeks. In addition, the manufacturer product labeling should be consulted for management guidelines in the event of a reduction in corrected serum calcium levels below the lower limit of the normal range and/or symptoms of hypocalcemia. Patients should also be advised to contact their health care professional if they experience symptoms of hypocalcemia, such as numbness or tingling in the fingers, toes, or around the mouth, muscle spasms, twitches or cramps, seizures, confusion, and irregular heartbeats.

Aclasta

Generic Name: zoledronic acid

Brand name: Aclasta, Zometa, Reclast, Zometa Concentrate

Synonyms: n.a.

What is Aclasta?

Etelcalcetide Hydrochloride

Generic Name: etelcalcetide

Brand name: Parsabiv

Synonyms: Etelcalcetide

What is Etelcalcetide Hydrochloride?