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Aclidinium and Formoterol and ProvayBlue

Determining the interaction of Aclidinium and Formoterol and ProvayBlue and the possibility of their joint administration.

Check result:

Aclidinium and Formoterol <> ProvayBlue

Relevance: 05.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using formoterol together with methylene blue may increase cardiovascular side effects such as heart palpitations, chest pain, increased heart and pulse rates, and blood pressure elevations. The risk exists even when formoterol or similar medications are given by oral inhalation directly into the lungs, and more so if these products are overused. Talk to your doctor before using these medications if you have a history of heart disease or high blood pressure. Depending on your condition, it may be preferable to wait at least 14 days after you are off methylene blue before you start using formoterol. Do not exceed the dose and frequency of use of formoterol recommended on the product label or prescribed by your doctor. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Monoamine oxidase inhibitors (MAOIs) can potentiate the cardiovascular adverse effects of beta-2 adrenergic agonists such as hypertension, palpitation, tachycardia, and chest pain.

MANAGEMENT: Cardiovascular status should be closely monitored when beta-2 agonists are coadministered with MAOIs or other agents that possess MAOI activity (e.g., furazolidone, linezolid, methylene blue, procarbazine). Preferably, at least 14 days should elapse between discontinuation of MAOI therapy and initiation of treatment with beta-2 agonists.

References

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"Product Information. Brovana (arformoterol)." Sepracor Inc, Marlborough, MA.
"Product Information. Brethaire (terbutaline)." Novartis Pharmaceuticals, East Hanover, NJ.
Finch JS "Cardiovascular toxicity: clinical evaluation of albuterol, isoproterenol and placebo in rising dose tolerance trial." Ann Allergy 47 (1981): 402-4
"Product Information. Arcapta Neohaler (indacaterol)." Novartis Pharmaceuticals, East Hanover, NJ.
"Product Information. Foradil (formoterol)" Novartis Pharmaceuticals, East Hanover, NJ.
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"Product Information. Proventil (albuterol)." Schering Laboratories, Kenilworth, NJ.
"Product Information. Alupent (metaproterenol)." Boehringer-Ingelheim, Ridgefield, CT.
"Product Information. Maxair (pirbuterol)." 3M Pharmaceuticals, St. Paul, MN.
"Product Information. Severent (salmeterol)." Glaxo Wellcome, Research Triangle Park, NC.
"Product Information. Isuprel (isoproterenol)." Sanofi Winthrop Pharmaceuticals, New York, NY.
"Product Information. Breo Ellipta (fluticasone-vilanterol)." GlaxoSmithKline, Research Triangle Park, NC.
"Product Information. Striverdi Respimat (olodaterol)." Boehringer Ingelheim, Ridgefield, CT.
"Product Information. S2 Inhalant (racepinephrine)." Nephron Pharmaceuticals, Orlando, FL.
"Product Information. Tornalate Metered Dose (bitolterol)." Dura Pharmaceuticals, San Diego, CA.
"Adverse effects and complications of treatment with beta-adrenergic agonist drugs. Committee on drugs, the American Academy of Allergy and Immunology." J Allergy Clin Immunol 75 (1985): 443-9

Aclidinium and Formoterol

Generic Name: aclidinium / formoterol

Brand name: Duaklir Pressair

Synonyms: n.a.

What is Aclidinium and Formoterol?

ProvayBlue

Generic Name: methylene blue

Brand name: ProvayBlue, Urolene Blue

Synonyms: Provayblue (injection)

What is ProvayBlue?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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