Acthar Gel, H.P. and Bisoprolol

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Corticotropin may reduce the effects of bisoprolol in lowering blood pressure. The interaction is most likely to occur when corticotropin is used for more than a week, since prolonged use can cause sodium and water retention. Let your doctor know if you experience sudden, unexplained weight gain or swelling of the hands, ankles, or feet. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Corticosteroids may antagonize the effects of antihypertensive medications by inducing sodium and fluid retention. These effects may be more common with the natural corticosteroids (cortisone, hydrocortisone) because they have greater mineralocorticoid activity. Conversely, some calcium channel blockers such as diltiazem and verapamil may increase corticosteroid plasma levels and effects by inhibiting their clearance via CYP450 3A4 metabolism.

MANAGEMENT: Patients on prolonged (i.e., longer than about a week) or high-dose corticosteroid therapy should have blood pressure, electrolyte levels, and body weight monitored regularly, and be observed for the development of edema and congestive heart failure. The dosages of antihypertensive medications may require adjustment.

Acthar Gel, H.P.

Generic Name: corticotropin

Brand name: Acthar Gel, HP, Acthar, ACTH Gel, ACTH-80, ACTH-40 HP

Synonyms: H.P. Acthar Gel

What is Acthar Gel, H.P.?

Bisoprolol

Generic Name: bisoprolol

Brand name: Zebeta

Synonyms: n.a.

What is Bisoprolol?