Acthrel and Aldurazyme

• Generic Name: corticorelin
• Dosage Forms: injection, powder, lyophilized, for solution
• Other Brand Names: Acthrel

Acthrel is a man-made form of a hormone that occurs naturally in the body.

Acthrel is used as part of a medical test in people with Cushing's syndrome. Cushing syndrome is caused by high levels of cortisol (a steroid hormone produced by the adrenal gland).

Acthrel is also used to help your doctor determine why your body is producing too much of its own cortisol.

Acthrel may also be used for purposes not listed in this medication guide.

• Generic Name: laronidase
• Dosage Forms: injection, solution, concentrate
• Other Brand Names: Aldurazyme

Aldurazyme (laronidase) contains an enzyme that occurs naturally in the body in healthy people. Some people lack this enzyme because of a genetic disorder. Laronidase helps replace this missing enzyme in such people.

Aldurazyme is used to treat some of the symptoms of a genetic condition called mucopolysaccharidosis or MPS I, also called Hurler syndrome, Hurler-Scheie syndrome, or Scheie syndrome.

MPS I is a metabolic disorder in which the body lacks the enzyme needed to break down certain substances. These substances can build up in the body, causing enlarged organs, abnormal bone structure, changes in facial features, breathing problems, heart problems, vision or hearing loss, and changes in mental or physical abilities.

Aldurazyme may improve breathing and walking ability in people with this condition. However, this medication is not a cure for MPS I.