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Actiq and Atripla

Determining the interaction of Actiq and Atripla and the possibility of their joint administration.

Check result:

Actiq <> Atripla

Relevance: 05.02.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Efavirenz may reduce the blood levels of fentaNYL, which may make the medication less effective in treating your pain. Additionally, if you have been receiving treatment with fentaNYL, adding efavirenz may cause you to experience unpleasant withdrawal symptoms such as watery eyes, runny nose, sneezing, yawning, excessive sweating, goose bumps, fever, chills, flushing, restlessness, irritability, anxiety, depression, pupil dilation, tremor, rapid heart beat, body aches, involuntary twitching and kicking, abdominal cramping, loss of appetite, nausea, vomiting, diarrhea, and weight loss. On the other hand, if you have been receiving both medications, discontinuing efavirenz may increase the blood levels of fentaNYL, which could lead to an overdose. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR CLOSELY: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of opioids that are primarily metabolized by the isoenzyme such as butorphanol, fentanyl, hydrocodone, and oxycodone. Reduced efficacy or withdrawal symptoms may occur in patients maintained on their narcotic pain regimen following the addition of a CYP450 3A4 inducer. Conversely, discontinuation of the inducer may increase opioid plasma concentrations and potentiate the risk of overdose and fatal respiratory depression.

MANAGEMENT: Pharmacologic response to the opioid should be monitored more closely whenever a CYP450 3A4 inducer is added to or withdrawn from therapy, and the opioid dosage adjusted as necessary.

References

"Product Information. Mycobutin (rifabutin)." Pharmacia and Upjohn, Kalamazoo, MI.
"Product Information. Butorphanol Tartrate (butorphanol)." Apotex Corporation, Weston, FL.
"Product Information. Rifadin (rifampin)." Hoechst Marion-Roussel Inc, Kansas City, MO.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Product Information. OxyContin (oxycodone)." Purdue Frederick Company, Norwalk, CT.
"Product Information. Ionsys (fentanyl)." Ortho McNeil Pharmaceutical, Raritan, NJ.
"Product Information. Duragesic Transdermal System (fentanyl)." Janssen Pharmaceutica, Titusville, NJ.
Cerner Multum, Inc. "Australian Product Information." O 0
Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
"Product Information. Zohydro ER (HYDROcodone)." Zogenix, Inc, San Diego, CA.

Actiq

Generic Name: fentanyl

Brand name: Actiq, Abstral, Fentora, Subsys, Duragesic, Ionsys, Lazanda, Onsolis, Sublimaze

Synonyms: n.a.

What is Actiq?

Atripla

Generic Name: efavirenz / emtricitabine / tenofovir

Brand name: Atripla

Synonyms: n.a.

What is Atripla?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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