Activase and Aminocaproic Acid Oral Liquid
Determining the interaction of Activase and Aminocaproic Acid Oral Liquid and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using aminocaproic acid together with alteplase may reduce the effectiveness of both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of an antifibrinolytic agent (e.g., aminocaproic acid, tranexamic acid, aprotinin) in combination with a tissue plasminogen activator (t-PA) may reduce the therapeutic effects of both drugs due to opposing pharmacodynamic actions. Aminocaproic acid and tranexamic acid are competitive inhibitors of plasminogen activation. At high concentrations they can also directly inhibit plasmin, which is needed for the degradation of fibrin and thrombolysis. Aprotinin is a broad-spectrum protease inhibitor that inhibits plasmin. It is known to have antifibrinolytic activity and may interact with t-PAs in a similar fashion.
MANAGEMENT: No specific intervention is warranted, but clinicians should be alert to the potential for diminished therapeutic efficacy if a tissue plasminogen activator is administered to a patient who has been treated with an antifibrinolytic agent, and vice versa.
- "Product Information. LYSTEDA (tranexamic acid)." Xanodyne Pharmaceuticals Inc, Newport, KY.
- "Product Information. Cyklokapron (tranexamic acid)." Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. Trasylol (aprotinin)." Bayer, West Haven, CT.
- "Product Information. Amicar (aminocaproic acid)." Immunex Corporation, Seattle, WA.
Generic Name: alteplase
Brand name: Activase, Cathflo Activase
Synonyms: n.a.
Generic Name: aminocaproic acid
Brand name: Amicar
Synonyms: Aminocaproic acid, Aminocaproic Acid
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Activase-Aminocaproic Acid Oral Solution
- Activase-Aminocaproic Acid Tablets
- Activase-Aminofen
- Activase-Aminoglutethimide
- Activase-Aminolevulinic acid
- Activase-Aminolevulinic Acid (Systemic)
- Aminocaproic Acid Oral Liquid-Activated Charcoal
- Aminocaproic Acid Oral Liquid-Activated Charcoal Capsules and Tablets
- Aminocaproic Acid Oral Liquid-Activated Charcoal Liquid
- Aminocaproic Acid Oral Liquid-Active FE
- Aminocaproic Acid Oral Liquid-Active OB
- Aminocaproic Acid Oral Liquid-Activella