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Activase and Nitrolingual

Determining the interaction of Activase and Nitrolingual and the possibility of their joint administration.

Check result:

Activase <> Nitrolingual

Relevance: 21.03.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using nitroglycerin together with alteplase may decrease the effects of alteplase. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Limited data suggest that average plasma tPA levels and tPA-induced thrombolysis may be significantly reduced in the presence of nitroglycerin. The mechanism is not known, but may be due to nitroglycerin-induced increases in hepatic blood flow, which may result in increased hepatic metabolism of tPA. Isosorbide may theoretically also have an effect.

MANAGEMENT: While more data are needed, clinicians are warned of the possibility of decreased effectiveness of alteplase when these drugs are given together.

References

Nicolini FA, Ferrini D, Ottani F, et al. "Concurrent nitroglycerin therapy impairs tissue-type plasminogen activator-induced thrombolysis in patients with acute myocardial infarction." Am J Cardiol 74 (1994): 662-6
White CM, Fan CD, Chen BP, Kluger J, Chow MSS "Assessment of the drug interaction between alteplase and nitroglycerin: An in vitro study." Pharmacotherapy 20 (2000): 380-2
Romeo F, Rosano GMC, Martuscelli E, Deluca F, Bianco C, Colistra C, Comito M, Cardona N, Miceli F, Rosano V, Mehta JL "Concurrent nitroglycerin administration reduces the efficacy of recombinant tissue-type plasminogen activator in patients with acute anterior wall myocardial infarction." Am Heart J 130 (1995): 692-7

Activase

Generic Name: alteplase

Brand name: Activase, Cathflo Activase

Synonyms: n.a.

What is Activase?

Nitrolingual

Generic Name: nitroglycerin

Brand name: Gonitro, Nitrolingual, NitroMist, Nitrostat, Nitro-Time, Gonitro, Minitran, Nitro TD Patch-A, Nitro-Dur, Nitro-Bid, Nitrol Appli-Kit, Rectiv

Synonyms: n.a.

What is Nitrolingual?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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