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Active OB and Inderal

Determining the interaction of Active OB and Inderal and the possibility of their joint administration.

Check result:

Active OB <> Inderal

Relevance: 01.04.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using propranolol together with multivitamin, prenatal may decrease the effects of propranolol. Separate the administration times of propranolol and multivitamin, prenatal by at least 2 hours. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Concurrent administration with calcium salts may decrease the oral bioavailability of atenolol and possibly other beta-blockers. The exact mechanism of interaction is unknown. In six healthy subjects, calcium 500 mg (as lactate, carbonate, and gluconate) reduced the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of atenolol (100 mg) by 51% and 32%, respectively. The elimination half-life increased by 44%. Twelve hours after the combination, beta-blocking activity (as indicated by inhibition of exercise tachycardia) was reduced compared to that with atenolol alone. However, during a 4-week treatment in six hypertensive patients, there was no difference in blood pressure values between treatments. The investigators suggest that prolongation of the elimination half-life induced by calcium coadministration may have led to atenolol cumulation during long-term dosing, which compensated for the reduced bioavailability.

MANAGEMENT: It may help to separate the administration times of beta-blockers and calcium products by at least 2 hours. Patients should be monitored for potentially diminished beta-blocking effects following the addition of calcium therapy.

References

Kirch W, Schafer-Korting M, Axthelm T, Kohler H, Mutschler E "Interaction of atenolol with furosemide and calcium and aluminum salts." Clin Pharmacol Ther 30 (1981): 429-35

Active OB

Generic Name: multivitamin, prenatal

Brand name: NataChew, Select-OB, A-Free Prenatal, Azesco, CitraNatal 90 DHA, CitraNatal Assure, CitraNatal B-Calm, Materna, Pramilet FA, Stuartnatal Plus, Natalins Rx, Norlac RX, Neo-Forte, Mynatal, Zenate Advanced Formula, Prenatal MR 90, O-Cal-FA, Equi-Natal Plus, Pan OB Forte, Hi-Nate 90, Lactocal-F, Maternity-90, Prenazyme 1+1, Pre-H-Cal, Femnatal, Vynatal 1 Plus 1, Par-F, Maternity, Niferex PN Forte, Prenavite, Mynatal PN, Obnate 90, Maternal 90, Mynatal Rx, PreCare, Natarex, Ternamar, Aminatal Plus, Elemental Iron-90, Mynatal PN Forte, Mynatal FC, Mynate 90 Plus, Vitamed Prenatal Formula, Zitamin, Preterna, Vernate, Vernate Advanced, Prenate 90, Aminate, Mission Prenatal Rx, Niferex-PN, Marnatal-F, Prenate Ultra, Prenatal Z Advanced Formula, Prenatal Plus, Zenate Prenatal, NatalCare, Prenatal Plus with Beta-Carotene, Prenatal Rx, Maternity plus Beta Carotene, Equi-Natal M, Equi-Natal Rx, Equinatal 90, Equi-Natal Z, Natalcare Pic Forte, Natalcare Pic, Natalins, Stuart Prenatal with Beta Carotene, Prenatal MR 90 Fe, Aminatal Plus One, Aminate with 90 mg Iron, Ultra NatalCare, Prenatal S, Natafort, Nestabs, Nestabs CBF, Vitafol PN, Fem-Natal, Ami-Natal Plus One Improved, Aminatal Plus New Formula, Prenatal Plus with 27 mg Iron, Obegyn, Mission Prenatal, Mission Prenatal FA, Mission Prenatal HP, Mynatal Z, Mynatal Plus, Mynatal Ultracap, Prenatal Plus Iron, Prenatal 1 Plus 1, Natalcare Plus, Prenatal MTR with Selenium, Natalcare Rx, Prenavite FC, Prenavite PC, Chromagen OB, Natatab CFe, Natatab FA, Vitelle Nestabs OTC, NataChew, Premesis Rx, Prenate Advanced Formula, Precare Conceive, Citracal Prenatal Rx, Advanced NatalCare, NutriNate, Nestabs Rx, Stuartnatal Plus 3, Strongstart, Anemagen OB, Ultra-Natal, NatalCare Three, Natatab Rx, Equi-Natal Care, Inatal Advance, Inatal Ultra, Maternity Vitamin Low Iron, Ob-20, Prenatabs CBF, Prenatal Rx Low Iron, Vinate 90, Vinate M, Vinate Ultra, Prenate GT, Ferrex PC Forte, Trinate, Prenatal AD, Prenatal 19, Natalcare, Prenatal H, Duet Chewable, Natalfirst, Natelle, Cenogen Ultra, Prenatal-U, Nestabs FA, Vinate GT, Natafolic-PN, Cal-Nate, Icar Prenatal, Prenate Advance, Novastart, Novanatal, Natacaps, O-Cal Prenatal, NatalCare Advanced-RF, Duet DHA, Prenatabs OBN, Icare Prenatal Rx, Vinatal 600, Nutrispire, PrimaCare One, PrenaFirst, Natafolic-OB, , Choice-OB+DHA, Select-OB+DHA, Stuart One

Synonyms: n.a.

What is Active OB?

Inderal

Generic Name: propranolol

Brand name: Inderal LA, Inderal XL, InnoPran XL, Inderal, Hemangeol, InnoPran XL

Synonyms: n.a.

What is Inderal?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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