Activella Oral and Symproic

• Generic Name: estradiol / norethindrone
• Dosage Forms: tablet, film coated
• Other Brand Names: Activella, Mimvey, CombiPatch

Estradiol and norethindrone combination is used to treat moderate to severe hot flashes and other symptoms of menopause. It is also used to treat changes in and around the vagina (such as vaginal dryness, itching, and burning) caused by low estrogen levels or menopause. This medicine is also used to treat certain conditions in women before menopause if their ovaries do not make enough estrogens naturally, and prevent osteoporosis after menopause.

This medicine is a combination of two hormones: an estrogen hormone (estradiol) and a progestin hormone (norethindrone). It works by preventing symptoms, such as feelings of warmth in the face, neck, and chest, or sudden strong feelings of heat and sweating (hot flashes) in women during menopause.

This medicine is available only with your doctor's prescription.

• Generic Name: naldemedine
• Dosage Forms: tablet
• Other Brand Names: Symproic

Symproic (naldemedine) blocks certain effects of opioid medication. An opioid is sometimes called a narcotic.

Symproic reduces constipation caused by opioid pain medicine used to treat severe chronic pain. Naldemedine works by treating constipation without reducing the pain-relieving effects of the narcotic.

Symproic as been shown to be effective in people who have taken opioid pain medicines (for at least 4 weeks) to treat chronic pain that is not caused by cancer.