Activella Oral and Tolmetin Sodium

• Generic Name: estradiol / norethindrone
• Dosage Forms: tablet, film coated
• Other Brand Names: Activella, Mimvey, CombiPatch

Estradiol and norethindrone combination is used to treat moderate to severe hot flashes and other symptoms of menopause. It is also used to treat changes in and around the vagina (such as vaginal dryness, itching, and burning) caused by low estrogen levels or menopause. This medicine is also used to treat certain conditions in women before menopause if their ovaries do not make enough estrogens naturally, and prevent osteoporosis after menopause.

This medicine is a combination of two hormones: an estrogen hormone (estradiol) and a progestin hormone (norethindrone). It works by preventing symptoms, such as feelings of warmth in the face, neck, and chest, or sudden strong feelings of heat and sweating (hot flashes) in women during menopause.

This medicine is available only with your doctor's prescription.

• Generic Name: tolmetin
• Dosage Forms: n.a.
• Other Brand Names:

  Tolectin, Tolectin DS, Tolectin 600

Consider potential benefits and risks of tolmetin therapy as well as alternative therapies before initiating therapy with the drug. Use lowest possible effective dosage and shortest duration of therapy consistent with patient's treatment goals.

Symptomatic treatment of osteoarthritis and rheumatoid arthritis.

Management of juvenile rheumatoid arthritis in children ≥2 years of age.

Has been reported to be effective in the management of ankylosing spondylitis (late stages did not respond as well as early stages); has also been used with some success in the treatment of adhesive capsulitis shoulder (frozen shoulder), radiohumeral bursitis (tennis elbow), and local trauma (e.g., recent sprains).