Actonel with Calcium and Mycophenolate Mofetil Capsules
Determining the interaction of Actonel with Calcium and Mycophenolate Mofetil Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using calcium carbonate together with mycophenolate mofetil may decrease the effects of mycophenolate mofetil. You should separate the administration times of the medications by at least two hours. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Coadministration with antacids may decrease the oral bioavailability of mycophenolic acid. The exact mechanism of interaction is unknown but may involve chelation with polyvalent ions in antacids or enhanced drug solubility induced by an increase in gastric pH, or both. The interaction has been reported with magnesium/aluminum-containing antacids.
MANAGEMENT: Patients treated with oral mycophenolic acid who require an antacid or antacid-containing preparation (e.g., didanosine buffered tablets or pediatric oral solution) should separate the administration times of the medications by at least two hours.
- "Product Information. Myfortic (mycophenolic acid)." Novartis Pharmaceuticals, East Hanover, NJ.
- "Product Information. CellCept (mycophenolate mofetil)." Roche Laboratories, Nutley, NJ.
- Lipsky JJ "Mycophenolate mofetil." Lancet 348 (1996): 1357-9
- Bullingham R, Shah J, Goldblum R, Schiff M "Effects of food and antacid on the pharmacokinetics of single doses of mycophenolate mofetil in rheumatoid arthritis patients." Br J Clin Pharmacol 41 (1996): 513-6
Generic Name: calcium carbonate / risedronate
Brand name: Actonel with Calcium, Actonel and Calcium
Synonyms: n.a.
Generic Name: mycophenolate mofetil
Brand name: Cellcept, Myfortic, MMF
Synonyms: Mycophenolate mofetil (oral/injection), Mycophenolate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Actonel with Calcium-Mycophenolate Mofetil Injection
- Actonel with Calcium-Mycophenolate Mofetil Injection Solution
- Actonel with Calcium-Mycophenolate Mofetil Oral Suspension
- Actonel with Calcium-Mycophenolate mofetil oral/injection
- Actonel with Calcium-Mycophenolate Mofetil Tablets
- Actonel with Calcium-Mycophenolate sodium
- Mycophenolate Mofetil Capsules-Actoplus Met
- Mycophenolate Mofetil Capsules-Actoplus Met XR
- Mycophenolate Mofetil Capsules-Actos
- Mycophenolate Mofetil Capsules-Acuflex
- Mycophenolate Mofetil Capsules-Acular
- Mycophenolate Mofetil Capsules-Acular eent