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Actoplus Met and Aminoglutethimide

Determining the interaction of Actoplus Met and Aminoglutethimide and the possibility of their joint administration.

Check result:

Actoplus Met <> Aminoglutethimide

Relevance: 04.08.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

According to the manufacturer, aminoglutethimide may possibly induce the metabolism of antidiabetic agents. The clinical significance is unknown. Monitoring of glycemic control may be advisable during coadministration. Dose adjustments may be necessary if an interaction is suspected.

References

Lonning PE, Lnning PE "Aminoglutethimide enzyme induction: pharmacological and endocrinological implications." Cancer Chemother Pharmacol 26 (1990): 241-4
Kvinssland S, Lonning PE, Ueland PM "Aminoglutethimide as an inducer of microsomal enzymes. Part 1: Pharmacological aspects." Breast Cancer Res Treat 7 (1986): s73-6

Actoplus Met

Generic Name: metformin / pioglitazone

Brand name: Actoplus Met, Actoplus Met XR

Synonyms: n.a.

What is Actoplus Met?

Aminoglutethimide

Generic Name: aminoglutethimide

Brand name:

Synonyms: Aminoglutethimide (Oral)

What is Aminoglutethimide?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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