Actoplus Met and Cresemba (Isavuconazonium Sulfate Capsules)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Isavuconazonium may increase the blood levels and effects of metFORMIN. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with isavuconazonium sulfate (prodrug of isavuconazole) may increase the plasma concentration and effects of metformin. The proposed mechanism is inhibition of organic cation transporter 2 (OCT2)-mediated elimination by isavuconazole. Coadministration of isavuconazole sulfate with metformin increased metformin AUC by 52% and Cmax by 23%.

MANAGEMENT: Caution is advised if isavuconazonium sulfate (prodrug of isavuconazole) is used concomitantly with metformin. Dose adjustments of metformin as well as clinical and laboratory monitoring of glycemic control may be appropriate whenever isavuconazole sulfate is added to or withdrawn from therapy. Patients should be advised to be alert to potential signs and symptoms of hypoglycemia such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitations, and tachycardia.

Actoplus Met

Generic Name: metformin / pioglitazone

Brand name: Actoplus Met, Actoplus Met XR

Synonyms: n.a.

What is Actoplus Met?

Cresemba (Isavuconazonium Sulfate Capsules)

Generic Name: isavuconazonium

Brand name: Cresemba

Synonyms: Cresemba

What is Cresemba (Isavuconazonium Sulfate Capsules)?