Actoplus Met and Diltia XT
Determining the interaction of Actoplus Met and Diltia XT and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using dilTIAZem together with pioglitazone can increase the effects of pioglitazone, which can lead to hypoglycemia (low blood sugar). This can cause headache, dizziness, drowsiness, nausea, hunger, tremor, weakness, sweating, and palpitations. Talk with your doctor before using dilTIAZem while you are using pioglitazone. You may need a dose adjustment and you may need to check your blood sugar more often. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Pioglitazone is metabolized by CYP450 3A4 microsomal enzymes in the liver. The clinician should be aware of the potential for an interaction when pioglitazone is used in combination with another medication that inhibits and is also metabolized by CYP450 3A4.
MANAGEMENT: Monitoring for clinical and laboratory evidence of altered safety and efficacy of both drugs if pioglitazone is added to or removed from the patients medication regimen is recommended. Patients should be advised to regularly monitor their blood sugar, counseled on how to recognize and treat hypoglycemia (e.g., headache, dizziness, drowsiness, nausea, tremor, hunger, weakness, or palpitations) and to notify their physician if it occurs.
- "Product Information. Actos (pioglitazone)" Takeda Pharmaceuticals America, Lincolnshire, IL.
Generic Name: metformin / pioglitazone
Brand name: Actoplus Met, Actoplus Met XR
Synonyms: n.a.
Generic Name: diltiazem
Brand name: Cardizem CD, Cartia XT, Dilt-XR, Diltia XT, Taztia XT, Tiazac, Cardizem, Dilacor XR, Dilt-CD, Diltzac, Matzim LA, Tiazac, Cardizem LA, Tiazac Extended Release Capsules
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Actoplus Met-Diltiazem
- Actoplus Met-Diltiazem 12-Hour Sustained-Release Capsules
- Actoplus Met-Diltiazem CD
- Actoplus Met-Diltiazem Extended Release Tablets
- Actoplus Met-Diltiazem Hydrochloride
- Actoplus Met-Diltiazem Injection
- Diltia XT-Actoplus Met XR
- Diltia XT-Actos
- Diltia XT-Acuflex
- Diltia XT-Acular
- Diltia XT-Acular eent
- Diltia XT-Acular LS