Actoplus Met and Pitolisant Hydrochloride
Determining the interaction of Actoplus Met and Pitolisant Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Coadministration with pitolisant may increase plasma concentrations of substrates of the hepatic and intestinal uptake transporter, organic cation transporter 1 (OCT1). Pitolisant has demonstrated inhibitory potential towards OCT1 in vitro. The clinical significance of this effect has not been established. MANAGEMENT: Caution is recommended when pitolisant is administered with OCT1 substrates. References Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Professional:MONITOR: Coadministration with pitolisant may increase plasma concentrations of substrates of the hepatic and intestinal uptake transporter, organic cation transporter 1 (OCT1). Pitolisant has demonstrated inhibitory potential towards OCT1 in vitro. The clinical significance of this effect has not been established.
MANAGEMENT: Caution is recommended when pitolisant is administered with OCT1 substrates.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: metformin / pioglitazone
Brand name: Actoplus Met, Actoplus Met XR
Synonyms: n.a.
Generic Name: pitolisant
Brand name: Wakix
Synonyms: Pitolisant
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Actoplus Met-Pitressin
- Actoplus Met-Pitressin Injection
- Actoplus Met-Pitressin Synthetic
- Actoplus Met-Placidyl
- Actoplus Met-Plan B
- Actoplus Met-Plan B One-Step
- Pitolisant Hydrochloride-Actoplus Met XR
- Pitolisant Hydrochloride-Actos
- Pitolisant Hydrochloride-Acuflex
- Pitolisant Hydrochloride-Acular
- Pitolisant Hydrochloride-Acular eent
- Pitolisant Hydrochloride-Acular LS