Actoplus Met and Ranolazine ER Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ranolazine may increase the blood levels and effects of metFORMIN. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Ranolazine may reduce the renal clearance of drugs that are substrates of the organic cation transporter 2 (OCT2). The mechanism is inhibition of OCT2-mediated elimination by ranolazine. During concomitant use of metformin 1000 mg twice a day with ranolazine 500 mg to 1000 mg twice a day in subjects with type 2 diabetes, the plasma exposure to metformin increased by 1.4-fold and 1.8-fold, respectively.

MANAGEMENT: It may be advisable to monitor patients for altered efficacy and safety if ranolazine must be used with an OCT2 substrate.

Actoplus Met

Generic Name: metformin / pioglitazone

Brand name: Actoplus Met, Actoplus Met XR

Synonyms: n.a.

What is Actoplus Met?

Ranolazine ER Tablets

Generic Name: ranolazine

Brand name: Ranexa

Synonyms: Ranolazine

What is Ranolazine ER Tablets?