Actoplus Met and Tikosyn

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using dofetilide together with metFORMIN may increase the effects of dofetilide. Contact your doctor if you experience dizziness, fainting, irregular heartbeats, or palpitations. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The major pathway for elimination of dofetilide is through glomerular filtration and active tubular secretion using the cation transport system. Competition for this elimination pathway by other drugs may potentially result in increased levels of dofetilide and increase the risk of QT interval prolongation and ventricular arrhythmias. The clinician should be aware of the potential for an interaction when dofetilide is used in combination with another medication that is excreted via this pathway.

MANAGEMENT: The manufacturer recommends that the patient be closely monitored if these drugs are coadministered.

Actoplus Met

Generic Name: metformin / pioglitazone

Brand name: Actoplus Met, Actoplus Met XR

Synonyms: n.a.

What is Actoplus Met?

Tikosyn

Generic Name: dofetilide

Brand name: Tikosyn

Synonyms: n.a.

What is Tikosyn?